Table 2 Number of biopsy and detection on T790M
1st | 2nd | 3rd | 4th | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Tissue biopsy (Individual test) | |||||||||||
T790M positive | 21 | 2 | 0 | 1 | 24 | ||||||
With original mutation | 26 | 5 | 3 | 3 | 37 | ||||||
Total | 31 | 6 | 3 | 3 | 43 | ||||||
Tissue biopsy (Cumulative test) | |||||||||||
T790M positive | 21 | 23 | 23 | 24 | 24 | ||||||
Cumulative sensitivity | 0.81 | 0.79 | 0.77 | 0.77 | 0.77 | ||||||
Total | 31 | 37 | 40 | 43 | 43 | ||||||
1st | 2nd | 3rd | 4th | 5th | 6th | 7th | 8th | 9th | 10th | Total | |
Liquid biopsy (Individual test) | |||||||||||
T790M positive | 3 | 4 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 11 |
With original mutation | 13 | 5 | 4 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 28 |
Total | 37 | 17 | 11 | 7 | 7 | 7 | 5 | 4 | 2 | 1 | 98 |
Liquid biopsy (Cumulative test) | |||||||||||
T790M positive | 3 | 7 | 8 | 8 | 8 | 9 | 10 | 11 | 11 | 11 | 11 |
Cumulative sensitivity | 0.13 | 0.21 | 0.2 | 0.18 | 0.17 | 0.17 | 0.18 | 0.19 | 0.19 | 0.19 | 0.19 |
Total | 37 | 54 | 65 | 72 | 79 | 86 | 91 | 95 | 97 | 98 | 98 |