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Table 2 Number of biopsy and detection on T790M

From: Genetic diagnostic features after failure of initial treatment with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors among non-small-cell lung cancer patients harboring EGFR mutations

  1st 2nd 3rd 4th        Total
Tissue biopsy (Individual test)
T790M positive 21 2 0 1        24
 With original mutation 26 5 3 3        37
Total 31 6 3 3        43
Tissue biopsy (Cumulative test)
T790M positive 21 23 23 24        24
 Cumulative sensitivity 0.81 0.79 0.77 0.77        0.77
Total 31 37 40 43        43
  1st 2nd 3rd 4th 5th 6th 7th 8th 9th 10th Total
Liquid biopsy (Individual test)  
T790M positive 3 4 1 0 0 1 1 1 0 0 11
 With original mutation 13 5 4 1 1 2 1 1 0 0 28
Total 37 17 11 7 7 7 5 4 2 1 98
Liquid biopsy (Cumulative test)
T790M positive 3 7 8 8 8 9 10 11 11 11 11
 Cumulative sensitivity 0.13 0.21 0.2 0.18 0.17 0.17 0.18 0.19 0.19 0.19 0.19
Total 37 54 65 72 79 86 91 95 97 98 98