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Fig. 2 | BMC Cancer

Fig. 2

From: The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia

Fig. 2

Median intracellular MTX-PG and folate levels during four consecutive courses. Measurements were performed in n = 8 patients at start of protocol M and in n = 43 patients every 2 weeks after a HD-MTX and LV course at time of qualification for the next course. Both intracellular MTX-PG (a) and folate (b) levels increased significantly during protocol M over time (p < 0.001). The ratio folate/MTX-PG (c) decreased significantly over time (p < 0.001). The bold line represents the median levels of patients over time. This Figure was created using Graphpad Prism version 8.3

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