Table 5 Kaplan–Meier analysis of the association between MIR17HG variants and OS and PFS of glioma patients
SNP ID | Genotype | OS | PFS | ||||||
|---|---|---|---|---|---|---|---|---|---|
Event/ Total | SR (1−/3-year) | MST (month) | Log-rank p | Event/ Total | SR (1−/3-year) | MST (month) | Log-rank p | ||
Overall | |||||||||
rs17735387 | GG | 356/395 | 0.299/0.082 | 11.0 | 0.070 | 355/394 | 0.157/0.088 | 8.0 | 0.026 |
GA | 153/174 | 0.360/0.101 | 12.0 | 150/170 | 0.216/0.094 | 8.0 | |||
AA | 18/23 | 0.435/− | 12.0 | 18/23 | 0.304/− | 9.0 | |||
rs72640334 | CC | 433/487 | 0.319/0.092 | 11.0 | 0.365 | 430/483 | 0.179/0.092 | 8.0 | 0.470 |
CA | 86/96 | 0.333/0.082 | 10.0 | 85/95 | 0.179/0.093 | 8.0 | |||
AA | 7/7 | 0.143/− | 10.0 | 7/7 | 0.286/− | 8.0 | |||
rs7318578 | AA | 263/294 | 0.335/0.085 | 12.0 | 0.755 | 262/293 | 0.192/0.083 | 8.0 | 0.527 |
AC | 160/180 | 0.306/0.093 | 11.0 | 159/178 | 0.163/0.097 | 8.0 | |||
CC | 102/116 | 0.319/0.111 | 11.0 | 101/115 | 0.176/− | 8.0 | |||
rs7336610 | TT | 129/144 | 0.326/0.095 | 11.0 | 0.740 | 129/144 | 0.174/0.096 | 8.0 | 0.516 |
TC | 281/314 | 0.296/0.085 | 11.0 | 279/312 | 0.167/0.089 | 8.0 | |||
CC | 116/133 | 0.381/0.095 | 12.0 | 114/130 | 0.221/0.098 | 8.0 | |||
rs75267932 | AA | 425/479 | 0.323/0.091 | 11.0 | 0.766 | 422/475 | 0.185/0.092 | 8.0 | 0.634 |
AG | 92/103 | 0.311/0.095 | 10.0 | 91/102 | 0.176/0.097 | 8.0 | |||
GG | 10/10 | 0.400/− | 12.0 | 10/10 | 0.100/− | 8.0 | |||
Low-grade glioma (I-II) | |||||||||
rs17735387 | GG | 232/260 | 0.292/0.090 | 11.0 | 0.032 | 232/260 | 0.158/0.093 | 8.0 | 0.013 |
GA | 86/102 | 0.398/0.149 | 12.0 | 84/100 | 0.255/0.135 | 9.0 | |||
AA | 12/16 | 0.500/− | 12.0 | 12/16 | 0.375/− | 9.0 | |||
Females | |||||||||
rs72640334 | CC | 196/221 | 0.335/0.100 | 12.0 | 0.035 | 195/219 | 0.168/0.094 | 8.0 | 0.049 |
CA | 36/39 | 0.205/− | 9.0 | 35/38 | 0.105/− | 6.0 | |||
AA | 6/6 | 0.167/− | 10.0 | 6/6 | −/− | 8.0 | |||
Age ≥ 40 years | |||||||||
rs17735387 | GG | 217/232 | 0.246/0.051 | 10.0 | 0.002 | 216/231 | 0.134/0.059 | 8.0 | 0.002 |
GA | 78/86 | 0.360/0.081 | 12.0 | 78/86 | 0.178/0.080 | 8.0 | |||
AA | 7/11 | 0.303/− | 16.0 | 7/11 | 0.545 | 13.0 | |||