Table 3 Comparison of SEQ and HRM detected in Exon 19 and 21 mutation positive samples
HRM Detected | SEQ Detected | p value | Sensitivity | Specificity | PPV | NPV | Accuracy | |
|---|---|---|---|---|---|---|---|---|
Positive (%) | Negative (%) | |||||||
Positive (Exon 19) | 47 (72.3) | 18 (27.7) | <  0.001 | 100% | 74% | 72.3% | 100% | 84.4% |
Negative (Exon 19) | 0 (0) | 51 (100) | ||||||
Positive (Exon 21) | 15 (60) | 10 (40) | 0.002 | 100% | 90.1% | 60% | 100% | 91.3% |
Negative (Exon 21) | 0 (0) | 91 (100) | ||||||