AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality

BMC Cancer

Table 3 Lung cancer risk^a by cg05575921 percent methylation, restricted to 2014 USPSTF^b lung cancer screening-eligible pairs

	All lung cancer cases^c			Adenocarcinoma			Squamous cell carcinoma			Small cell
cg05575921 methylation %	Control	Case	OR (95% CI)	Control	Case	OR (95% CI)	Control	Case	OR (95% CI)	Control	Case	OR (95% CI)
cg05575921 methylation %	n	n	OR (95% CI)	n	n	OR (95% CI)	n	n	OR (95% CI)	n	n	OR (95% CI)
Continuous 10% decrease	242	242	0.90 (0.74, 1.08)	98	98	1.08 (0.79, 1.46)	82	82	0.76 (0.51, 1.12)	53	53	0.51 (0.28, 0.93)
Q1 (highest; hyper-methylated)	40	43	Ref	21	21	Ref	7	11	Ref	11	10	Ref
Q2	51	59	1.05 (0.51, 2.16)	19	22	1.39 (0.42, 4.62)	21	21	0.27 (0.04, 1.88)	9	16	2.84 (0.32, 25.21)
Q3	51	44	0.77 (0.33, 1.79)	21	16	1.46 (0.35, 6.16)	14	12	0.12 (0.01, 1.42)	13	12	0.48 (0.05, 4.46)
Q4	46	40	0.55 (0.23, 1.34)	22	14	1.06 (0.28, 4.05)	17	17	0.13 (0.01, 1.41)	6	7	0.01 (0.00, 0.56)
Q5 (lowest; hypo-methylated)	54	56	0.77 (0.33, 1.78)	15	25	1.87 (0.47, 7.46)	23	21	0.17 (0.02, 1.50)	14	8	0.52 (0.04, 6.22)
	P-trend		0.29	P-trend		0.55	P-trend		0.23	P-trend		0.05

Abbreviations: CI confidence interval, NSCLC non-small cell lung cancer, NSCLC, NOS non-small cell lung cancer, not otherwise specified, OR odds ratio, USPSTF United States Preventive Services Task Force
^aLogistic regression model results, conditioned on matching factors (age at blood draw ±5 years, smoking status, sex, race, asbestos, enrollment year ±2 years, and time at risk) and adjusted for age at blood draw, estimated cell type, and cigarettes per day at blood draw
^bIndividuals aged 55–80 with at least 30 pack-year smoking histories who are current or former smokers who had quit within the past 15 years
^c“All lung cancer cases” includes adenocarcinoma, squamous cell, and small cell, as well as 9 cases for whom histotype was NSCLC, NOS; other NSCLC; unknown or missing

ISSN: 1471-2407