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Table 3 Lung cancer riska by cg05575921 percent methylation, restricted to 2014 USPSTFb lung cancer screening-eligible pairs

From: AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality

  All lung cancer casesc Adenocarcinoma Squamous cell carcinoma Small cell
cg05575921
methylation %
Control Case OR (95% CI) Control Case OR (95% CI) Control Case OR (95% CI) Control Case OR (95% CI)
n n n n n n n n
Continuous 10% decrease 242 242 0.90 (0.74, 1.08) 98 98 1.08 (0.79, 1.46) 82 82 0.76 (0.51, 1.12) 53 53 0.51 (0.28, 0.93)
Q1 (highest; hyper-methylated) 40 43 Ref 21 21 Ref 7 11 Ref 11 10 Ref
Q2 51 59 1.05 (0.51, 2.16) 19 22 1.39 (0.42, 4.62) 21 21 0.27 (0.04, 1.88) 9 16 2.84 (0.32, 25.21)
Q3 51 44 0.77 (0.33, 1.79) 21 16 1.46 (0.35, 6.16) 14 12 0.12 (0.01, 1.42) 13 12 0.48 (0.05, 4.46)
Q4 46 40 0.55 (0.23, 1.34) 22 14 1.06 (0.28, 4.05) 17 17 0.13 (0.01, 1.41) 6 7 0.01 (0.00, 0.56)
Q5 (lowest; hypo-methylated) 54 56 0.77 (0.33, 1.78) 15 25 1.87 (0.47, 7.46) 23 21 0.17 (0.02, 1.50) 14 8 0.52 (0.04, 6.22)
  P-trend 0.29 P-trend 0.55 P-trend 0.23 P-trend 0.05
  1. Abbreviations: CI confidence interval, NSCLC non-small cell lung cancer, NSCLC, NOS non-small cell lung cancer, not otherwise specified, OR odds ratio, USPSTF United States Preventive Services Task Force
  2. aLogistic regression model results, conditioned on matching factors (age at blood draw ±5 years, smoking status, sex, race, asbestos, enrollment year ±2 years, and time at risk) and adjusted for age at blood draw, estimated cell type, and cigarettes per day at blood draw
  3. bIndividuals aged 55–80 with at least 30 pack-year smoking histories who are current or former smokers who had quit within the past 15 years
  4. c“All lung cancer cases” includes adenocarcinoma, squamous cell, and small cell, as well as 9 cases for whom histotype was NSCLC, NOS; other NSCLC; unknown or missing