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Table 2 Lung cancer riska by cg05575921 percent methylation for all lung cancer cases and by histotype

From: AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality

  All lung cancer casesb Adenocarcinoma Squamous cell carcinoma Small cell
cg05575921
methylation %
Control Case OR (95% CI) Control Case OR (95% CI) Control Case OR (95% CI) Control Case OR (95% CI)
n n n n n n n n
Continuous 10% decrease 316 316 0.93 (0.79, 1.10) 132 132 1.10 (0.85, 1.42) 103 103 0.77 (0.54, 1.11) 71 71 0.70 (0.46, 1.07)
Q1 (highest; hyper-methylated) 63 59 Ref 33 28 Ref 11 15 Ref 17 15 Ref
Q2 64 78 1.52 (0.81, 2.83) 23 35 2.41 (0.90, 6.46) 26 23 0.32 (0.07, 1.54) 13 19 2.40 (0.54, 10.60)
Q3 63 59 0.95 (0.47, 1.93) 27 20 1.48 (0.47, 4.63) 17 16 0.17 (0.03, 1.11) 16 19 1.08 (0.25, 4.60)
Q4 63 49 0.60 (0.28, 1.27) 32 18 0.95 (0.31, 2.89) 22 20 0.16 (0.02, 1.05) 8 9 0.30 (0.04, 2.42)
Q5 (lowest; hypo-methylated) 63 71 1.03 (0.49, 2.16) 17 31 2.58 (0.77, 8.61) 27 29 0.23 (0.04, 1.37) 17 9 0.49 (0.07, 3.22)
  P-trend 0.38 P-trend 0.50 P-trend 0.26 P-trend 0.12
  1. Abbreviations: CI confidence interval, NSCLC non-small cell lung cancer, NSCLC, NOS non-small cell lung cancer, not otherwise specified, OR Odds ratio
  2. aLogistic regression model results, conditioned on matching factors (age at blood draw ±5 years, smoking status, sex, race, asbestos, enrollment year ±2 years, and time at risk) and adjusted for age at blood draw, estimated cell type, and cigarettes per day at blood draw
  3. b“All lung cancer cases” includes adenocarcinoma, squamous cell, and small cell, as well as 10 cases for whom histotype was NSCLC, NOS; other NSCLC; unknown or missing