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Table 2 Lung cancer riska by cg05575921 percent methylation for all lung cancer cases and by histotype

From: AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality

 

All lung cancer casesb

Adenocarcinoma

Squamous cell carcinoma

Small cell

cg05575921

methylation %

Control

Case

OR (95% CI)

Control

Case

OR (95% CI)

Control

Case

OR (95% CI)

Control

Case

OR (95% CI)

n

n

n

n

n

n

n

n

Continuous 10% decrease

316

316

0.93 (0.79, 1.10)

132

132

1.10 (0.85, 1.42)

103

103

0.77 (0.54, 1.11)

71

71

0.70 (0.46, 1.07)

Q1 (highest; hyper-methylated)

63

59

Ref

33

28

Ref

11

15

Ref

17

15

Ref

Q2

64

78

1.52 (0.81, 2.83)

23

35

2.41 (0.90, 6.46)

26

23

0.32 (0.07, 1.54)

13

19

2.40 (0.54, 10.60)

Q3

63

59

0.95 (0.47, 1.93)

27

20

1.48 (0.47, 4.63)

17

16

0.17 (0.03, 1.11)

16

19

1.08 (0.25, 4.60)

Q4

63

49

0.60 (0.28, 1.27)

32

18

0.95 (0.31, 2.89)

22

20

0.16 (0.02, 1.05)

8

9

0.30 (0.04, 2.42)

Q5 (lowest; hypo-methylated)

63

71

1.03 (0.49, 2.16)

17

31

2.58 (0.77, 8.61)

27

29

0.23 (0.04, 1.37)

17

9

0.49 (0.07, 3.22)

 

P-trend

0.38

P-trend

0.50

P-trend

0.26

P-trend

0.12

  1. Abbreviations: CI confidence interval, NSCLC non-small cell lung cancer, NSCLC, NOS non-small cell lung cancer, not otherwise specified, OR Odds ratio
  2. aLogistic regression model results, conditioned on matching factors (age at blood draw ±5 years, smoking status, sex, race, asbestos, enrollment year ±2 years, and time at risk) and adjusted for age at blood draw, estimated cell type, and cigarettes per day at blood draw
  3. b“All lung cancer cases” includes adenocarcinoma, squamous cell, and small cell, as well as 10 cases for whom histotype was NSCLC, NOS; other NSCLC; unknown or missing