All lung cancer casesb | Adenocarcinoma | Squamous cell carcinoma | Small cell | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
cg05575921 methylation % | Control | Case | OR (95% CI) | Control | Case | OR (95% CI) | Control | Case | OR (95% CI) | Control | Case | OR (95% CI) |
n | n | n | n | n | n | n | n | |||||
Continuous 10% decrease | 316 | 316 | 0.93 (0.79, 1.10) | 132 | 132 | 1.10 (0.85, 1.42) | 103 | 103 | 0.77 (0.54, 1.11) | 71 | 71 | 0.70 (0.46, 1.07) |
Q1 (highest; hyper-methylated) | 63 | 59 | Ref | 33 | 28 | Ref | 11 | 15 | Ref | 17 | 15 | Ref |
Q2 | 64 | 78 | 1.52 (0.81, 2.83) | 23 | 35 | 2.41 (0.90, 6.46) | 26 | 23 | 0.32 (0.07, 1.54) | 13 | 19 | 2.40 (0.54, 10.60) |
Q3 | 63 | 59 | 0.95 (0.47, 1.93) | 27 | 20 | 1.48 (0.47, 4.63) | 17 | 16 | 0.17 (0.03, 1.11) | 16 | 19 | 1.08 (0.25, 4.60) |
Q4 | 63 | 49 | 0.60 (0.28, 1.27) | 32 | 18 | 0.95 (0.31, 2.89) | 22 | 20 | 0.16 (0.02, 1.05) | 8 | 9 | 0.30 (0.04, 2.42) |
Q5 (lowest; hypo-methylated) | 63 | 71 | 1.03 (0.49, 2.16) | 17 | 31 | 2.58 (0.77, 8.61) | 27 | 29 | 0.23 (0.04, 1.37) | 17 | 9 | 0.49 (0.07, 3.22) |
P-trend | 0.38 | P-trend | 0.50 | P-trend | 0.26 | P-trend | 0.12 |