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Table 7 Functional enrichment analysis for pCR and RELAPSE models

From: Prediction of prognostic signatures in triple-negative breast cancer based on the differential expression analysis via NanoString nCounter immune panel

Category Term Genes aP Value
bpCR
 GOTERM_BP_DIRECT GO:0006955 ~ immune response IL2RA, CCL20, HAMP, CD1A, CCL5, CD7 1.95E-07
 UP_SEQ_FEATURE disulfide bond FCER1A, IL2RA, CCL20, HAMP, CD1A, CCL5, SELE, CD7 1.36E-06
 UP_SEQ_FEATURE signal peptide FCER1A, IL2RA, CCL20, HAMP, CD1A, CCL5, SELE, CD7 3.57E-06
 UP_KEYWORDS Disulfide bond FCER1A, IL2RA, CCL20, HAMP, CD1A, CCL5, SELE, CD7 3.58E-06
 UP_KEYWORDS Signal FCER1A, IL2RA, CCL20, HAMP, CD1A, CCL5, SELE, CD7 1.37E-05
 KEGG_PATHWAY hsa04640:Hematopoietic cell lineage IL2RA, CD1A, CD7 0.002295
 KEGG_PATHWAY hsa04668:TNF signaling pathway CCL20, CCL5, SELE 0.003452
 KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction IL2RA, CCL20, CCL5 0.016968
 KEGG_PATHWAY hsa05323:Rheumatoid arthritis CCL20, CCL5 0.074368
cRELAPSE
 UP_SEQ_FEATURE disulfide bond FCER1A, IL2RA, CCL8, GZMB, CCL5, CCL7, EDNRB, IL17B, TNFSF13B, CLEC4E, TGFBI, CSF2RB, SELE 8.75E-11
 UP_KEYWORDS Disulfide bond FCER1A, IL2RA, CCL8, GZMB, CCL5, CCL7, EDNRB, IL17B, TNFSF13B, CLEC4E, TGFBI, CSF2RB, SELE 4.58E-10
 UP_SEQ_FEATURE signal peptide FCER1A, EDNRB, IL17B, IL2RA, TGFBI, CCL8, CSF2RB, GZMB, CCL5, SELE, CCL7 7.83E-07
 UP_KEYWORDS Cytokine IL17B, TNFSF13B, CCL8, CCL5, CCL7 3.29E-06
 GOTERM_BP_DIRECT GO:0006954 ~ inflammatory response IL17B, IL2RA, CCL8, CCL5, SELE, CCL7 3.97E-06
 UP_KEYWORDS Signal FCER1A, EDNRB, IL17B, IL2RA, TGFBI, CCL8, CSF2RB, GZMB, CCL5, SELE, CCL7 4.97E-06
 UP_KEYWORDS Glycoprotein FCER1A, EDNRB, IL17B, IL2RA, CLEC4E, TNFSF13B, CSF2RB, GZMB, CCL5, SELE, CCL7 1.17E-05
 KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction IL17B, IL2RA, TNFSF13B, CCL8, CSF2RB, CCL5, CCL7 7.28E-07
 KEGG_PATHWAY hsa04062:Chemokine signaling pathway CCL8, CCL5, CCL7 0.034067
  1. Only annotations with a FDR < 0.05 after multiple hypothesis testing are presented from DAVID outputs
  2. a: Original P value (FDR < 0.05) calculated in DAVID
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