Fig. 5

Model-simulated contribution of proteins stimulating apoptosis of mitotically-arrested cells. Simulation of the effect of combined 10 nM PTX and 100 nM BRP to stimulate apoptosis of mitotically-arrested cells. The simulation is based on the final protein-based cell cycle and apoptosis model of Fig. 1b, in which the k_apm stimulation term is regulated by ASPP2, BAX, Bcl2, and cIAP1. Each stimulation term was modeled by a power function, with the protein expression raised to a power coefficient γ, i.e., \( \mathrm{sti}={\left(\mathrm{i}\right)}^{\upgamma_{\mathrm{i}}} \). The y-axis shows the strength of the k_apm stimulation over time, expressed as the fold change for each protein i over time to the power coefficient γ (\( {k}_{amp}={k}_{apm0}\cdot \mathrm{ASPP}{2}_2\cdot {cIAP}^{\gamma_{cIAP}}\cdot \frac{{\mathrm{BAX}}^{\upgamma_{\mathrm{BAX}}}}{\mathrm{Bcl}2} \), with parameter values listed in Table 1).