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Fig. 6 | BMC Cancer

Fig. 6

From: Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model

Fig. 6

Viability of MPNST and PA28 (B8y) overexpressing cells as a function on 3-BrPA concentration without and with starvation. c(3-BrPA) – concentration of 3-BrPA; ∆FUnorm – normalized difference of fluorescence units. a Mean values of normalized differences in FU ± SEM are presented for MPNST cell lines. Results gained with media containing 10% FBS are indicated by full lines; under starvation at 0.2% FBS, cell lines are marked with an asterisk and results are displayed by dotted lines. Concentration ranges with significant differences (p < 0.05) in MPNST cell viability compared to starved cells are marked by horizontal lines and asterisks. b Mean values of normalized differences in FU ± SEM are presented for B8y cells without and with starvation. Concentration range with significant differences in B8y cell viability compared to starved cells is marked by horizontal lines and asterisks. c Relative changes in cell viability on 3-BrPA concentration for MPNST cell lines without and with starvation. Statistical significance (p-value < 0.05) is highlighted by asterisk. For details of statistics see Additional file 5.d) Relative changes in cell viability on 3-BrPA concentration for B8y cells without and with starvation. For details of statistics see Additional file 5

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