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Fig. 3 | BMC Cancer

Fig. 3

From: Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model

Fig. 3

Formation of ROS in PA28y overexpressing (B8y) and control cells (B8vc) in response to 3-BrPA treatment and nutrient deprivation. c(3-BrPA) – concentration of 3-BrPA; ∆FUnorm – normalized difference of fluorescence units. a Mean values of normalized differences in FU ± SEM are presented. Results under normal conditions (10% FBS) are indicated by full lines; under serum free conditions (0.2% FBS), cell lines are marked with an asterisk and results are displayed by dotted lines. Concentration ranges with significant differences (p < 0.05) in ROS formation compared to starved cells are marked by horizontal lines and asterisks. b Correlations between ROS formation and agent concentration as regression lines. For details of statistics see Additional file 2

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