| Univariable | Multivariable | ||
---|---|---|---|---|
HR | P | HR | P | |
Age | Â | 0.512 | Â | Â |
  ≤ 65 | 1 |  |  |  |
  > 65 | 1.127 (0.788–1.610) |  |  |  |
Sex | Â | 0.452 | Â | Â |
 Male | 0.872 (0.610–1.246) |  |  |  |
 Female | 1 |  |  |  |
ECOG PS | Â | 0.090 | Â | 0.092 |
 0 | 1 |  | 1 |  |
  ≥ 1 | 1.355 (0.953–1.926) |  | 1.372 (0.949–1.984) |  |
Charlson Commorbidity index | Â | 0.730 | Â | Â |
 0 | 1 |  |  |  |
  ≥ 1 | 1.066 (0.742–1.530) |  |  |  |
Chronic hepatitis B | Â | 0.246 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.328 (0.822–2.144) |  |  |  |
Chronic hepatitis C | Â | 0.736 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.187 (0.437–3.230) |  |  |  |
Liver cirrhosis | Â | 0.134 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.531 (0.877–2.673) |  |  |  |
Biliary drainage | Â | 0.884 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.043 (0.597–1.821) |  |  |  |
Tumor size | Â | 0.207 | Â | Â |
  ≤ 7 cm | 1 |  |  |  |
  > 7 cm | 0.799 (0.564, 1.132) |  |  |  |
Vascular invasion | Â | 0.346 | Â | Â |
 No | 1 |  |  |  |
 Yes | 0.841 (0.587, 1.206) |  |  |  |
Hilar invasion | Â | 0.752 | Â | Â |
 No | 1 |  |  |  |
 Yes | 0.914 (0.524, 1.596) |  |  |  |
Liver metastasis | Â | 0.686 | Â | Â |
 No | 1 |  |  |  |
 Yes | 0.930 (0.654–1.322) |  |  |  |
Extrahepatic organ metastasis | Â | 0.108 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.332 (0.939–1.889) |  |  |  |
Distant lymph node metastasis |  | < 0.001 |  | < 0.001 |
 No | 1 |  | 1 |  |
 Yes | 1.906 (1.309–2.775) |  | 1.929 (1.305–2.851) |  |
Number of metastatic sites | Â | Â | Â | Â |
 0 | 1 |  |  |  |
 1 | 2.753 (1.292–5.864) | 0.009 |  |  |
  ≥ 2 | 2.987 (1.434–6.221) | 0.003 |  |  |
Total bilirubin | Â | 0.604 | Â | Â |
  ≤ 1.5 x ULN | 1 |  |  |  |
  > 1.5 x ULN | 1.209 (0.590–2.480) |  |  |  |
Alkaline phosphatase | Â | 0.008 | Â | 0.125 |
  ≤ 1.5 x ULN | 1 |  | 1 |  |
  > 1.5 x ULN | 1.632 (1.138–2.340) |  | 1.337 (0.923–1.939) |  |
Albumin | Â | 0.001 | Â | 0.043 |
  < 3.5 g/dL | 2.268 (1.424–3.610) |  | 1.632 (1.017–2.618) |  |
  ≥ 3.5 g/dL | 1 |  | 1 |  |
CA 19–9 |  | 0.530 |  |  |
  ≤ 37 U/mL | 1 |  |  |  |
  > 37 U/mL | 1.118 (0.790–1.583) |  |  |  |
PLR |  | < 0.001 |  | 0.002 |
  ≤ 148 | 1 |  | 1 |  |
  > 148 | 2.332 (1.610–3.378) |  | 1.856 (1.266–2.723) |  |
NLR |  | < 0.001 |  |  |
  ≤ 5 | 1 |  |  |  |
  > 5 | 2.273 (1.471–3.512) |  |  |  |
LMR |  | < 0.001 |  | 0.041 |
  < 3.5 | 2.423 (1.516–3.875) |  | 1.691 (1.023–2.797) |  |
  ≥ 3.5 | 1 |  | 1 |  |
AGR | Â | 0.002 | Â | Â |
  < 1.2 | 1.768 (1.236–2.528) |  |  |  |
  ≥ 1.2 | 1 |  |  |  |