| Univariable | Multivariable | ||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age | Â | 0.148 | Â | Â |
  ≤ 65 | 1 |  |  |  |
  > 65 | 0.735 (0.484–1.116) |  |  |  |
Sex | Â | 0.149 | Â | Â |
 Male | 0.797 (0.489–1.115) |  |  |  |
 Female | 1 |  |  |  |
ECOG PS | Â | 0.518 | Â | Â |
 0 | 1 |  |  |  |
  ≥ 1 | 1.139 (0.767–1.692) |  |  |  |
Charlson Commorbidity index | Â | 0.697 | Â | Â |
 0 | 1 |  |  |  |
  ≥ 1 | 1.084 (0.722–1.626) |  |  |  |
Chronic hepatitis B | Â | 0.155 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.497 (0.934–2.320) |  |  |  |
Chronic hepatitis C | Â | 0.612 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.297 (0.475–3.547) |  |  |  |
Liver cirrhosis | Â | 0.157 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.551 (0.844–2.851) |  |  |  |
Biliary drainage | Â | 0.184 | Â | Â |
 No | 1 |  |  |  |
 Yes | 0.593 (0.275–1.281) |  |  |  |
Tumor size | Â | 0.394 | Â | Â |
  ≤ 7 cm | 1 |  |  |  |
  > 7 cm | 0.838 (0.558, 1.258) |  |  |  |
Vascular invasion | Â | 0.379 | Â | Â |
 No | 1 |  |  |  |
 Yes | 0.830 (0.548, 1.257) |  |  |  |
Hilar invasion | Â | 0.181 | Â | Â |
 No | 1 |  |  |  |
 Yes | 0.610 (0.296, 1.258) |  |  |  |
Liver metastasis | Â | 0.472 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.157 (0.777–1.723) |  |  |  |
Extrahepatic organ metastasis | Â | 0.280 | Â | Â |
 No | 1 |  |  |  |
 Yes | 1.246 (0.836–1.856) |  |  |  |
Distant lymph node metastasis | Â | 0.001 | Â | 0.001 |
 No | 1 |  | 1 |  |
 Yes | 2.135 (1.361–3.348) |  | 2.085 (1.329–3.272) |  |
Number of metastatic sites | Â | Â | Â | Â |
 0 | 1 |  |  |  |
 1 | 2.567 (1.064–6.194) | 0.036 |  |  |
  ≥ 2 | 3.422 (1.467–7.985) | 0.004 |  |  |
Total bilirubin | Â | 0.336 | Â | Â |
  ≤ 1.5 x ULN | 1 |  |  |  |
  > 1.5 x ULN | 0.611 (0.224–1.666) |  |  |  |
Alkaline phosphatase | Â | 0.765 | Â | Â |
  ≤ 1.5 x ULN | 1 |  |  |  |
  > 1.5 x ULN | 1.066 (0.703–1.616) |  |  |  |
Albumin | Â | 0.050 | Â | Â |
  < 3.5 g/dL | 1.725 (1.001–2.975) |  |  |  |
  ≥ 3.5 g/dL | 1 |  |  |  |
CA 19–9 |  | 0.818 |  |  |
  ≤ 37 U/mL | 1 |  |  |  |
  > 37 U/mL | 0.955 (0.643–1.417) |  |  |  |
PLR | Â | 0.006 | Â | 0.009 |
  ≤ 148 | 1 |  | 1 |  |
  > 148 | 1.828 (1.193–2.800) |  | 1.766 (1.155–2.703) |  |
NLR | Â | 0.030 | Â | Â |
  ≤ 5 | 1 |  |  |  |
  > 5 | 1.738 (1.056–2.859) |  |  |  |
LMR | Â | 0.087 | Â | Â |
  < 3.5 | 1.538 (0.939–2.520) |  |  |  |
  ≥ 3.5 | 1 |  |  |  |
AGR | Â | 0.368 | Â | Â |
  < 1.2 | 1.200 (0.807–1.786) |  |  |  |
  ≥ 1.2 | 1 |  |  |  |