From: Defining the optimal bilirubin level before hepatectomy for hilar cholangiocarcinoma
 | Bilirubin ≤75 μmol/L (n = 82) | Bilirubin > 75 μmol/L (n = 8) | P value |
---|---|---|---|
Blood loss (L) | 1.4 (0.3–20) | 3.12 (1.4–6.0) | 0.008a |
Blood replacement (L) | 0.0 (0.0–13.8) | 2.45 (0.6–4.3) | < 0.001a |
Blood transfusion | 34 (42.0%) | 8 (100%) | 0.011a |
Operation time (min) | 674.0 (222–1290) | 797.0 (514–960) | 0.156 |
Type of resection | Â | Â | 0.558 |
 Right hepatectomy | 5 (6.1%) | 1 (12.5%) |  |
 Right extended hepatectomy | 3 (3.7%) | 0 (0%) |  |
 Left hepatectomy | 2 (2.4%) | 1 (12.5%) |  |
 Left extended hepatectomy | 2 (2.4%) | 0 (0%) |  |
 Right trisectionectomy | 2 (2.4%) | 0 (0%) |  |
 Left trisectionectomy | 1 (1.2%) | 0 (0%) |  |
 Right hepatectomy + caudate | 26 (31.7%) | 1 (12.5%) |  |
 Right extended hepatectomy + caudate | 7 (8.5%) | 0 (0%) |  |
 Left hepatectomy + caudate | 12 (14.6%) | 3 (37.5%) |  |
 Left extended hepatectomy + caudate | 5 (6.1%) | 0 (0%) |  |
 Right trisectionectomy + caudate | 17 (20.7%) | 2 (25%) |  |
 Blood vessel reconstruction | 22 (26.8%) | 0 (0%) | 0.210 |
 Portal vein reconstruction | 17 (20.7%) | 0 (0%) | 0.339 |
 Hepatic artery reconstruction | 5 (6.1%) | 0 (0%) | 1.000 |
 Patients with postoperative complications | 46 (56.1%) | 6 (75%) | 0.510 |
 Renal complications | 6 (7.3%) | 3 (37.5%) | 0.036a |
  Urinary tract infection | 1 (1.2%) | 1 (12.5%) | 0.418 |
  Renal failure | 5 (6.1%) | 2 (25%) | 0.225 |
Patients with complications of grade IIIA or above | 28 (34.1%) | 4 (50%) | 0.612 |
 Grade IIIA | 24 (29.3%) | 3 (37.5%) | 0.936 |
 Grade IIIB | 14 (17.1%) | 1 (12.5%) | 1.000 |
 Grade IVA | 6 (7.3%) | 1 (12.5%) | 1.000 |
 Grade IVB | 0 (0%) | 0 (0%) | /// |
 Grade V | 7 (8.5%) | 4 (50%) | 0.004a |
In-hospital mortality | 7 (8.5%) | 4 (50%) | 0.004a |
30-day mortality | 5 (6.1%) | 2 (25%) | 0.225 |
90-day mortality | 8 (9.8%) | 4 (50%) | 0.008a |
Hospital stay (days) | 20.0 (6–93) | 27.5 (10–214) | 0.228 |
Pattern of recurrence | Â | Â | 0.394 |
 No recurrence | 31 (37.8%) | 5 (62.5%) |  |
 Intrahepatic recurrence | 7 (8.5%) | 0 (0%) |  |
 Extrahepatic recurrence | 22 (26.8%) | 2 (25%) |  |
 Intrahepatic and extrahepatic recurrence | 22 (26.8%) | 1 (12.5%) |  |
Time to recurrence (months) | 16.7 (1.2–218.3) | 11.6 (1.1–24.4) | 0.311 |
Follow-up duration (months) | 21.6 (0.4–218.3) | 4.1 (0.3–26.6) | 0.008a |
Resection margin | Â | Â | 1.000 |
 Not involved | 44 (53.7%) | 4 (50%) |  |
 Involved | 38 (46.3%) | 4 (50%) |  |
Invasion of major branch of portal or hepatic vein | Â | Â | 1.000 |
 No | 70 (85.4%) | 7 (87.5%) |  |
 Yes | 12 (14.6%) | 1 (12.5%) |  |
Microvascular invasion | Â | Â | 0.429 |
 Absent | 55 (67.1%) | 7 (87.5%) |  |
 Present | 27 (32.9%) | 1 (12.5%) |  |
Number of lymph node metastasis | 0.0 (0–25) | 0.0 (0–3) | 0.891 |
Klatskin staging | Â | Â | 0.208 |
 I | 12 (15.0%) | 0 (0%) |  |
 II | 25 (31.3%) | 3 (37.5%) |  |
 IIIA | 2 (2.5%) | 1 (12.5%) |  |
 IIIB | 26 (32.5%) | 4 (50%) |  |
 IVA | 12 (15.0%) | 0 (0%) |  |
 IVB | 3 (3.8%) | 0 (0%) |  |