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Table 3 Comparison of the two groups of patients in terms of intraoperative, postoperative and histopathological results

From: Defining the optimal bilirubin level before hepatectomy for hilar cholangiocarcinoma

 

Bilirubin

≤75 μmol/L

(n = 82)

Bilirubin

> 75 μmol/L

(n = 8)

P value

Blood loss (L)

1.4 (0.3–20)

3.12 (1.4–6.0)

0.008a

Blood replacement (L)

0.0 (0.0–13.8)

2.45 (0.6–4.3)

< 0.001a

Blood transfusion

34 (42.0%)

8 (100%)

0.011a

Operation time (min)

674.0 (222–1290)

797.0 (514–960)

0.156

Type of resection

  

0.558

 Right hepatectomy

5 (6.1%)

1 (12.5%)

 

 Right extended hepatectomy

3 (3.7%)

0 (0%)

 

 Left hepatectomy

2 (2.4%)

1 (12.5%)

 

 Left extended hepatectomy

2 (2.4%)

0 (0%)

 

 Right trisectionectomy

2 (2.4%)

0 (0%)

 

 Left trisectionectomy

1 (1.2%)

0 (0%)

 

 Right hepatectomy + caudate

26 (31.7%)

1 (12.5%)

 

 Right extended hepatectomy + caudate

7 (8.5%)

0 (0%)

 

 Left hepatectomy + caudate

12 (14.6%)

3 (37.5%)

 

 Left extended hepatectomy + caudate

5 (6.1%)

0 (0%)

 

 Right trisectionectomy + caudate

17 (20.7%)

2 (25%)

 

 Blood vessel reconstruction

22 (26.8%)

0 (0%)

0.210

 Portal vein reconstruction

17 (20.7%)

0 (0%)

0.339

 Hepatic artery reconstruction

5 (6.1%)

0 (0%)

1.000

 Patients with postoperative complications

46 (56.1%)

6 (75%)

0.510

 Renal complications

6 (7.3%)

3 (37.5%)

0.036a

  Urinary tract infection

1 (1.2%)

1 (12.5%)

0.418

  Renal failure

5 (6.1%)

2 (25%)

0.225

Patients with complications of grade IIIA or above

28 (34.1%)

4 (50%)

0.612

 Grade IIIA

24 (29.3%)

3 (37.5%)

0.936

 Grade IIIB

14 (17.1%)

1 (12.5%)

1.000

 Grade IVA

6 (7.3%)

1 (12.5%)

1.000

 Grade IVB

0 (0%)

0 (0%)

///

 Grade V

7 (8.5%)

4 (50%)

0.004a

In-hospital mortality

7 (8.5%)

4 (50%)

0.004a

30-day mortality

5 (6.1%)

2 (25%)

0.225

90-day mortality

8 (9.8%)

4 (50%)

0.008a

Hospital stay (days)

20.0 (6–93)

27.5 (10–214)

0.228

Pattern of recurrence

  

0.394

 No recurrence

31 (37.8%)

5 (62.5%)

 

 Intrahepatic recurrence

7 (8.5%)

0 (0%)

 

 Extrahepatic recurrence

22 (26.8%)

2 (25%)

 

 Intrahepatic and extrahepatic recurrence

22 (26.8%)

1 (12.5%)

 

Time to recurrence (months)

16.7 (1.2–218.3)

11.6 (1.1–24.4)

0.311

Follow-up duration (months)

21.6 (0.4–218.3)

4.1 (0.3–26.6)

0.008a

Resection margin

  

1.000

 Not involved

44 (53.7%)

4 (50%)

 

 Involved

38 (46.3%)

4 (50%)

 

Invasion of major branch of portal or hepatic vein

  

1.000

 No

70 (85.4%)

7 (87.5%)

 

 Yes

12 (14.6%)

1 (12.5%)

 

Microvascular invasion

  

0.429

 Absent

55 (67.1%)

7 (87.5%)

 

 Present

27 (32.9%)

1 (12.5%)

 

Number of lymph node metastasis

0.0 (0–25)

0.0 (0–3)

0.891

Klatskin staging

  

0.208

 I

12 (15.0%)

0 (0%)

 

 II

25 (31.3%)

3 (37.5%)

 

 IIIA

2 (2.5%)

1 (12.5%)

 

 IIIB

26 (32.5%)

4 (50%)

 

 IVA

12 (15.0%)

0 (0%)

 

 IVB

3 (3.8%)

0 (0%)

 
  1. Data are shown as number of patient (percent) or median (range)
  2. astatistically significant