Table 1 Examinations and visits schedule

Inform Consent form

●

Observance of oral targeted therapy^b

●

●

●

●

●^c

Medical history and comorbidities

●

Toxicities related to targeted therapy^d

●

●

●

●

Every 3 months

Adverse events related to physical activity^d

●

●

●

Clinical examination & vital signs^e

●

●

●

●

Every 3 months

Every 3 months^k

Survival Status

●

●

●

Every 3 months

Every 3 months^k

General QoL (FACT-G, EQ-5D-3L)^f

●

●

●

●

Every 3 months

Fatigue (FACT-F)^f

●

●

●

●

Every 3 months

Nutrition (FAACT module AC/S)

●

●

●

●

Every 3 months

Cognitive Function (FACT-Cog)

●

●

●

●

Every 3 months

Food intake VAS

●

●

Pain and fatigue VAS

●

●^g

●^g

●^g

Every 3 months

Adherence to targeted therapy (Morisky-Green)

●

●

●

●

Anxiety and Depression (HADS)

●

●

●

●

Daily physical activity

 ○ IPAQ

●

●

Every 3 months

 ○ Booklet

●

●

●

 ○ Questionning about the continuation of physical activity

Every 3 months

Muscle mass, muscle density, adipose tissue (VAT and SCAT), Evaluation (TAP-CT)

●

●

●^h

Physical capacitiesⁱ

E0

E1

E2

E3

Tumor evaluation^j

●

●

●^l

●^{k, l}

Scintigraphy

●

●

●

MRI

●

●

●

Biological Assessment^k

●

●

●

●

Experimental Arm

SPEP Program

Blood samples^m

●

●