TY - JOUR AU - Ortiz-Otero, Nerymar AU - Marshall, Jocelyn R. AU - Lash, Bradley AU - King, Michael R. PY - 2020 DA - 2020/09/11 TI - Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collective migration units with cancer-associated fibroblasts in metastatic cancer patients JO - BMC Cancer SP - 873 VL - 20 IS - 1 AB - Recent studies have shown that chemotherapy destabilizes the blood vasculature and increases circulating tumor cell (CTC) influx into the circulation of metastatic cancer patients (Met-pa). CTCs are a precursor of cancer metastasis, in which they can migrate as single CTCs or as CTC clusters with stromal cells such as cancer-associated fibroblasts (CAFs) as cell aggregates. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-020-07376-1 DO - 10.1186/s12885-020-07376-1 ID - Ortiz-Otero2020 ER -