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Fig. 5 | BMC Cancer

Fig. 5

From: Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

Fig. 5

SOX2 elevation decreases the expression of multiple cyclins and CDKs. a-d Western blot analyses of the cyclins indicated in whole cell extracts harvested from i-SOX2-LNCaP, i-SOX2-ONS76, i-SOX2-HPAF-II, and i-SOX2-BE(2)C cells after 48 h culture in the presence or absence of Dox at the concentration indicated. e-h Western blot analyses of the CDKs indicated in whole cell extracts harvested from i-SOX2-LNCaP, i-SOX2-ONS76, i-SOX2-HPAF-II, and i-SOX2-BE(2)C cells after 48 h culture in the presence or absence of Dox at the concentration indicated. Western blot analyses of cyclins and CDKs were repeated using separate whole extracts for each cell line and similar results were obtained

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BMC Cancer

ISSN: 1471-2407

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