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Table 1 Associations between smoking-associated mutational signature and expression of candidate genes (Bonferroni-correction P < 0.01)

From: From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes

Cancer type

Gene

Beta

P

head and neck

(N = 495)

NFE2L2

0.54

4.1 × 10−11

RMND5A

0.56

2.0 × 10−10

SLC44A1

0.56

2.9 × 10−10

ARRB1

−0.46

5.1 × 10− 8

FAM60A

0.44

5.8 × 10− 8

RHOG

−0.43

5.9 × 10− 8

lung adenocarcinoma

(N = 507)

GPR15

0.44

2.2 × 10− 16

NWD1

−0.40

2.0 × 10− 13

HDGF

0.42

1.9 × 10− 12

AHRR

0.34

6.6 × 10−10

KCNQ1

−0.29

3.9 × 10− 8

CAPN8

−0.27

4.4 × 10− 8

RPS6KA1

− 0.30

5.0 × 10− 8

  1. “N” refers to sample size for each cancer type. A regression analysis was constructed to include tobacco smoking-associated mutational signature as a dependent variable and gene expression levels as the independent variable for each gene of each cancer type
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BMC Cancer

ISSN: 1471-2407

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