Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes

Fig. 3

Mediation analysis illustrating the effect of tobacco smoking-altered methylation on gene expression in lung adenocarcinoma. a Scatter plots indicating the statistical significance of associations between methylations at three candidate CpG sites and tobacco smoking in lung adenocarcinoma. b Scatter plots indicating negative correlations between DNA methylation at three candidate CpG sites and gene expression in lung adenocarcinoma.c A diagram to illustrate a mediation analysis framework, where DNA methylation can be a mediator to affect the expression of tobacco smoking-altered genes. d Two candidate CpG sites are presented with significant mediation effects on gene expression, at P < 0.05. “ACME” refers to the average causal mediation effects via DNA methylation on gene expression

Back to article page