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Fig. 4 | BMC Cancer

Fig. 4

From: ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K/AKT and NF-κB signaling pathway

Fig. 4

ERCC6L down-regulation inhibits PI3K/AKT and NF-κB pathway activation. SMMC7721(a) and HuH-7 cells (b) were transfected with shERCC6L, ERCC6L or NC for 72 h. Cell lysates were isolated and the expression of proteins involved in the PI3K/AKT and NF-κB pathway were analyzed by western blot. NC, cells transfected with empty vector; shERCC6L, cells transfected with shERCC6L; ERCC6L, cells transfected with ERCC6L; ERCC6L+ Deguelin, cells transfected with ERCC6L and treated with 5 μM/L deguelin for 4 h. *P < 0.05 vs. NC cells; #P < 0.05 vs. ERCC6L. Dot plots represent one of three independent experiments. In the histogram, data are mean ± SD of three experiments

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