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Table 1 Univariate analysis of risk factors and occurrence of lymph node metastasis

From: Retrospective analysis of LNM risk factors and the effect of chemotherapy in early colorectal cancer: A Chinese multicenter study

Factors N LNM(−),n(%) LNM(+),n(%) P-value
N 288 271 17  
Gender     0.431
 Male 162 154 (53.47) 8 (47.06)  
 Female 126 117 (46.53) 9 (52.94)  
Age,χ ± SD (years old) 59.5 + 11.6 59.7 + 11.7 56.8 + 11.2 0.316
Smoking     0.084
 Positive 68 67 (23.26) 1 (5.88)  
 Negative 220 204 (76.74) 16 (94.12)  
Alcohol     0.520
 Positive 43 41 (15.13) 2 (11.76)  
 Negative 245 230 (84.87) 15 (88.24)  
Family history     0.557
 Positive 10 10 (3.69) (0.00)  
 Negative 278 261 (96.31) 17 (100.00)  
Tumor size, χ ± SD (mm) 30.0 ± 15.6 29.2 ± 15.4 38.3 ± 17.3 0.026*
Tumor location     0.115
 Rectum 186 171 (63.10) 15 (88.24)  
 Sigmoid colon 68 68 (25.09) 0  
 Ascending colon 19 17 (6.27) 2 (11.76)  
 Descending colon 10 10 (3.69) 0  
 Transverse colon 5 5 (1.85) 0  
Endoscopic morphology     0.703
 I (the uplift type) 248 232 (85.61) 16 (94.12)  
 II (the flat type) 7 7 (2.58) 0 (0.00)  
 III (the concave type) 25 24 (8.86) 1 (5.88)  
 Uncertain 8 8 (2.95) 0 (0.00)  
Pathology     < 0.001**
 Highly differentiated 78 78 (28.78) 0 (0.00)  
 Moderately differentiated 202 189 (69.74) 13 (76.47)  
 Poorly differentiated 8 4 (1.48) 4 (23.53)  
Depth of invasion     0.255
 Mucosal layer 76 74 (27.31) 2 (11.76)  
 Submucosal layer 212 197 (72.69) 15 (88.24)  
Lympho-vascular invasion     < 0.001**
 Positive 6 2 (0.74) 4 (23.53)  
 Negative 282 269 (99.26) 13 (76.47)  
Tumor budding     0.833
 Positive 3 3 (1.11) 0 (0.00)  
 Negative 285 268 (98.89) 17 (100.00)  
  1. Note: * P < 0.05, ** P < 0.01. LNM(−):No lymph node metastasis, LNM(+):Lymph node metastasis