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Table 2 Operative and postoperative outcomes in patients with LARC after NCRT

From: Worse treatment response to neoadjuvant chemoradiotherapy in young patients with locally advanced rectal cancer

Characteristics Young group (n = 75) Old group (n = 826) p value
Operative time (min) 232.5 ± 81.2 225.8 ± 64.0 0.394
Estimated blood loss (ml) 77.7 ± 74.2 88.9 ± 105.5 0.372
Surgery approach (%)    0.882
 Laparoscopic 49 (65.3) 549 (66.5)  
 Open 18 (24.0) 198 (23.9)  
 Robotic 8 (10.7) 79 (9.6)  
Postoperative hospital stay (days) 7.8 ± 3.4 8.8 ± 5.5 0.124
Postoperative complications (%) 12 (16.0) 122 (14.9) 0.736
30 days readmission (%) 1 (1.3) 5 (0.6) 0.407
Peri-CRT complicationsa 25 (33.3) 259 (31.4) 0.699
 Major 1 (1.3) 23 (2.8) 0.741
Sphincter-saving procedure (%) 66 (88.0) 721 (87.4) 1.000
Pathological type (%)    0.936
 Ulcering 72 (96.0) 796 (96.7)  
 Expanding 1 (1.3) 11 (1.2)  
 Infiltrating 2 (2.7) 19 (2.1)  
Histopathology (%)    0.008
 Adenocarcinoma 62 (82.7) 763 (92.4)  
 Mucinous or signet ring cell carcinoma 13 (17.3) 63 (7.6)  
Tumor differentiation (%)    < 0.001
 Well to moderately differentiated 57 (75.7) 752 (91.0)  
 Poorly differentiated and others 18 (24.3) 74 (9.0)  
Chemotherapy regimen (%)    0.461
 FOLFOX/CapeOX 33 (44.0) 326 (39.5)  
 Capecitabine 42 (56.0) 500 (60.5)  
Lymph nodes retrieved 19.3 ± 13.1 12.0 ± 6.2 < 0.001
Metastatic lymph nodes 2.2 ± 6.1 0.7 ± 2.0 < 0.001
CRM involvement (%) 1 (1.3) 10 (1.2) 1.000
Tumor size (cm)    0.069
  ≤ 1.8 cm 17(22.7) 212 (25.7)  
 1.9–3.1 cm 31 (41.3) 416 (50.4)  
  ≥ 3.2 cm 27 (36.0) 198 (24.0)  
Pathological TNM stage (%)    0.957
 0 9 (12.0) 183 (22.2)  
 I 14 (18.7) 205 (24.8)  
 II 16 (21.3) 217 (26.3)  
 III 31 (41.3) 179 (21.7)  
 IV 5 (6.7) 42 (5.2)  
TRG grade (%)    0.003
 0 9 (12.0) 183 (22.2)  
 1 20 (26.7) 272 (32.9)  
 2 33 (44.0) 313 (37.9)  
 3 13 (17.3) 58 (7.0)  
Perineural invasion (%) 13 (17.3) 54 (6.5) 0.002
Vascular invasion (%) 4 (5.3) 29 (3.5) 0.346
Adjuvant chemotherapy (%)    0.484
 Complete 44 (58.7) 427 (51.7)  
 Decreased complete 9 (12.0) 87 (10.5)  
 Refuse 2 (2.7) 44 (5.3)  
 Unknown 20 (26.7) 268 (32.4)  
  1. a Some patients experienced more than one complication, and categorized as
  2. NCRT Neoadjuvant chemoradiotherapy; CRM Circumferential resection margin; TRG Tumor regression grade