Survival analysis of patients with stage T2a and T2b perihilar cholangiocarcinoma treated with radical resection

Table 1 Comparison of basic clinicopathological characteristics of patients with stage T2a and T2b cholangiocarcinoma

Variable name	T2a (n = 80)	T2b (n = 98)	P value
Gender			0.231
Male	41	59
Female	39	39
Age (years)	62.0	59.0	0.018*
Maximum diameter (cm)	2.1	2.4	0.075
Intraoperative blood loss (mL)	300.0	500.0	<0.001*
TBIL (μmol/L)	175.6	153.2	0.424
DBIL (μmol/L)	153.1	136.4	0.355
IBIL (μmol/L)	17.8	17.7	0.532
ALT (IU/L)	98.5	112.0	0.807
AST (IU/L)	88.5	82.0	0.901
ALP (IU/L)	318.0	325.0	0.787
GGT (IU/L)	295.5	362.5	0.910
CA19–9 (U/mL)	184.7	283.3	0.119
CEA (ng/mL)	3.1	3.7	0.110
Cholelithiasis			0.437
With	22	22
Without	58	76
Preoperative biliary drainage			0.588
With	13	19
Without	67	79
Caudate lobe resection			<0.001*
With	44	91
Without	36	7
Vascular resection			0.870
With	2	4
Without	78	94
Perineural invasion			0.100
With	66	89
Without	14	9
Positive margin status			0.880
With	10	13
Without	70	85
Number of harvested LN			0.067
< 6	63	65
≥ 6	17	33
Adjuvant therapy			0.470
With	5	9
Without	75	89
Bismuth type			<0.001*
Type I/II	59	39
Type III/IV	21	59
Pathological differentiation			0.718
Well	6	8
Moderate	62	71
Poor	12	19
N staging(8th edition)			0.094
N0	61	60
N1	15	28
N2	4	10
Tumor stage (8th edition)			0.094
II	61	60
IIIC	15	28
IVA	4	10

NOTE. TBIL total bilirubin; DBIL direct bilirubin; IBIL indirect bilirubin; ALT alanine aminotransferase; AST aspartate amino transferase; ALP alkaline phosphatase; GGT gamma-glutamyl transpeptidase; CEA carcinoembryonic antigen; CA19–9 carbohydrate antigen 19–9; LN lymph node
The cutoff value of TBIL, DBIL, IBIL, ALT, AST, ALP, GGT were their median respectively. The cutoff value of CEA was the lower limit of threshold level. The cutoff value of CA19–9 was the upper limit of threshold level
* P value< 0.05