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Table 3 Univariate and multivariate analysis of factors with the OS of p-NENs using Cox Regression proportional hazard models

From: World Health Organization grading classification for pancreatic neuroendocrine neoplasms: a comprehensive analysis from a large Chinese institution

Factor

Univariate Analysis

WHO 2017 criteria Multivariate AnalysisA

WHO 2010 criteria Multivariate AnalysisA

HR(95%CIs) P

HR(95%CIs) P

HR(95%CIs) P

Gender

 MaleB

   

 Female

0.953 (0.467–3.252) 0.537

  

Age, yr.

  < Median

   

  ≥ Median

1.211 (0.587–1.256) 0.079

  

Tumor location

 Head

   

 Body/tail

1.436 (0.912–2.579) 0.408

  

Functional status

 Functional

   

 Non-functional

1.725 (0.436–3.926) 0.027

0.894 (0.583–1.457) 0.635

0.616 (0.589–1.368) 0.441

Incidental diagnosis

 No

   

 Yes

0.984 (0.457–1.562) 0.336

  

Radical resection

 Yes

   

 No

4.113 (0.384–7.335) < 0.001

0.993 (0.309–1.873) 0.009

1.023 (0.574–2.359) 0.015

Postoperative medical therapy

 Yes

 No

1.518 (0.366–2.735) 0.045

0.845 (0.673–1.419) 0.357

0.903 (0.449–1.525) 0.745

Tumor diameter

  < Median

  ≥ Median

1.005 (0.567–2.138) 0.024

0.665 (0.357–1.983) 0.341

0.883 (0.436–1.843) 0.452

Vascular infiltration

 No

 Yes

2.138 (0.543–4.113) 0.037

1.255 (0.843–2.059) 0.012

0.993 (0.519–1.725) 0.039

Lymph involvement

 No

 Yes

3.542 (0.343–6.25) 0.008

2.357 (0.331–5.369) 0.036

1.924 (0.536–3.454) 0.025

Distant metastasis

 No

 Yes

5.112 (0.478–10.205) < 0.001

4.124 (0.385–8.359) 0.027

2.445 (0.501–7.374) 0.048

Grading by WHO 2010 criteria

 NET G1/G2

 

 “NEC G3”

4.425 (0.454–14.346) < 0.001

NA

2.445 (0.201–13.374) 0.022

Grading by WHO 2017 criteria

 NET G1/G2/G3

 NEC G3

6.634 (0.634–8.257) < 0.001

4.562 (0.983–9.454) 0.016

NA

  1. A: Predicting value of the WHO 2017 and 2010 grading classification for the OS of p-NENs was built and evaluated in separate Regression proportional hazard models
  2. B: The above one of related factor was regarded as a reference in Cox analysis
  3. Abbreviation: OS Overall survival; p-NENs Pancreatic neuroendocrine neoplasms; WHO World Health Organization; HR Hazard ratio; CIs Confidence intervals; NET Neuroendocrine tumors; NEC Neuroendocrine carcinoma; G Grading; NA Not applicable