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Table 1 Demographic and clinicopathological characteristics by age at diagnosis

From: Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

Characteristic n (%) Age at diagnosis, years (percent within age group) P
< 50 50–59 60–69 70–79 > 80
Sex
 Male 11,886 (96.95) 574 (76.84) 2052 (78.50) 3830 (77.94) 3916 (74.95) 1514 (71.28)  
 Female 3738 (3.05) 173 (23.16) 562 (21.50) 1084 (22.06) 1309 (25.05) 610 (28.72) < 0.001
Year of diagnosis
 1988 to 2003 3717 (23.79) 221 (29.59) 649 (24.83) 1081 (22.00) 1323 (25.32) 443 (20.86)  
 2004 to 2015 11,907 (76.21) 526 (70.41) 1965 (75.17) 3833 (78.00) 3902 (74.68) 1681 (79.14) < 0.001
Race
 Caucasians 13,929 (89.15) 634 (84.87) 2260 (86.46) 4387 (89.28) 4718 (90.30) 1930 (90.87)  
 Afro-Americans 918 (5.88) 73 (9.77) 220 (8.42) 308 (6.27) 238 (4.56) 79 (3.72)  
 Other 751 (4.81) 37 (4.95) 128 (4.90) 211 (4.29) 264 (5.05) 111 (5.23)  
 Unknown 26 (0.17) 3 (0.40) 6 (0.23) 8 (0.16) 5 (0.10) 4 (0.19) < 0.001
Grade
 I 60 (0.38) 9 (1.20) 8 (0.31) 13 (0.26) 19 (0.36) 11 (0.52)  
 II 469 (3.00) 28 (3.75) 96 (3.67) 139 (2.83) 152 (2.91) 54 (2.54)  
 III 5388 (34.49) 272 (36.41) 907 (34.70) 1660 (33.78) 1836 (35.14) 713 (33.57)  
 IV 9181 (58.76) 415 (55.56) 1512 (57.84) 2948 (59.99) 3035 (58.09) 1271 (59.84)  
 Unknown 526 (3.37) 23 (3.08) 91 (3.48) 154 (3.13) 183 (3.50) 75 (3.53) 0.01
T stage
 T2 6353 (40.66) 331 (44.31) 1138 (43.53) 2141 (43.57) 2053 (39.29) 690 (32.49)  
 T3 6479 (41.47) 281 (37.62) 1034 (39.56) 1897 (38.60) 2230 (42.68) 1037 (48.82)  
 T4 2792 (17.87) 135 (18.07) 442 (16.91) 876 (17.83) 942 (18.03) 397 (18.69) < 0.001
  1. Characteristics differ by age group; Grade represents the degree of differentiation of bladder tumor (Grade I: Well differentiated, Grade II: Moderately differentiated, Grade III: Poorly differentiated, Grade IV: Undifferentiated); Year of diagnosis represents the time of diagnosis of MIBC; T stage represents the degree of invasion of bladder tumor