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Table 1 Demographic and clinicopathological characteristics by age at diagnosis

From: Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

Characteristic

n (%)

Age at diagnosis, years (percent within age group)

P

< 50

50–59

60–69

70–79

> 80

Sex

 Male

11,886 (96.95)

574 (76.84)

2052 (78.50)

3830 (77.94)

3916 (74.95)

1514 (71.28)

 

 Female

3738 (3.05)

173 (23.16)

562 (21.50)

1084 (22.06)

1309 (25.05)

610 (28.72)

< 0.001

Year of diagnosis

 1988 to 2003

3717 (23.79)

221 (29.59)

649 (24.83)

1081 (22.00)

1323 (25.32)

443 (20.86)

 

 2004 to 2015

11,907 (76.21)

526 (70.41)

1965 (75.17)

3833 (78.00)

3902 (74.68)

1681 (79.14)

< 0.001

Race

 Caucasians

13,929 (89.15)

634 (84.87)

2260 (86.46)

4387 (89.28)

4718 (90.30)

1930 (90.87)

 

 Afro-Americans

918 (5.88)

73 (9.77)

220 (8.42)

308 (6.27)

238 (4.56)

79 (3.72)

 

 Other

751 (4.81)

37 (4.95)

128 (4.90)

211 (4.29)

264 (5.05)

111 (5.23)

 

 Unknown

26 (0.17)

3 (0.40)

6 (0.23)

8 (0.16)

5 (0.10)

4 (0.19)

< 0.001

Grade

 I

60 (0.38)

9 (1.20)

8 (0.31)

13 (0.26)

19 (0.36)

11 (0.52)

 

 II

469 (3.00)

28 (3.75)

96 (3.67)

139 (2.83)

152 (2.91)

54 (2.54)

 

 III

5388 (34.49)

272 (36.41)

907 (34.70)

1660 (33.78)

1836 (35.14)

713 (33.57)

 

 IV

9181 (58.76)

415 (55.56)

1512 (57.84)

2948 (59.99)

3035 (58.09)

1271 (59.84)

 

 Unknown

526 (3.37)

23 (3.08)

91 (3.48)

154 (3.13)

183 (3.50)

75 (3.53)

0.01

T stage

 T2

6353 (40.66)

331 (44.31)

1138 (43.53)

2141 (43.57)

2053 (39.29)

690 (32.49)

 

 T3

6479 (41.47)

281 (37.62)

1034 (39.56)

1897 (38.60)

2230 (42.68)

1037 (48.82)

 

 T4

2792 (17.87)

135 (18.07)

442 (16.91)

876 (17.83)

942 (18.03)

397 (18.69)

< 0.001

  1. Characteristics differ by age group; Grade represents the degree of differentiation of bladder tumor (Grade I: Well differentiated, Grade II: Moderately differentiated, Grade III: Poorly differentiated, Grade IV: Undifferentiated); Year of diagnosis represents the time of diagnosis of MIBC; T stage represents the degree of invasion of bladder tumor