Skip to main content

Table 1 Baseline characteristics, and results of univariate and multivariate Cox regression analysis

From: Calculating the overall survival probability in patients with cervical cancer: a nomogram and decision curve analysis-based study

Variables N (%) Univariate analysis Multivariate analysis
HR (95% CI) P-value HR (95% CI) P-value
Age at diagnosis, years old
  < 45 4057 (41.079) Reference   Reference  
 45–59 3408 (34.508) 1.588 (1.436–1.756) < 0.001 1.110 (1.001–1.231) 0.047
  ≥ 60 2411 (24.413) 2.748 (2.491–3.031) < 0.001 1.536 (1.380–1.709) < 0.001
Race
 White 7572 (76.671) Reference   Reference  
 Black 1204 (12.191) 1.679 (1.513–1.863) < 0.001 1.282 (1.152–1.426) < 0.001
 Other 1100 (11.138) 1.062 (0.935–1.207) 0.356 1.083 (0.952–1.232) 0.226
Marital status at diagnosis
 Single 3020 (30.579) Reference   Reference  
 Married 4544 (46.011) 0.716 (0.652–0.787) < 0.001 0.852 (0.773–0.940) 0.001
 Other 2312 (23.410) 1.290 (1.169–1.424) < 0.001 1.101 (0.992–1.223) 0.072
Grade
 I 1482 (15.006) Reference   Reference  
 II 4285 (43.388) 2.546 (2.121–3.055) < 0.001 1.374 (1.138–1.659) 0.001
 III 4109 (41.606) 4.690 (3.924–5.604) < 0.001 1.732 (1.436–2.088) < 0.001
Histology
 SCC 6363 (64.429) Reference   Reference  
 AC 3113 (31.521) 0.633 (0.576–0.696) < 0.001 1.076 (0.974–1.189) 0.150
 Other 400 (4.050) 2.585 (2.242–2.980) < 0.001 1.757 (1.512–2.042) < 0.001
Tumor size
  < 4 cm 5315 (53.817) Reference   Reference  
  ≥ 4 cm 4561 (46.183) 5.084 (4.629–5.583) < 0.001 1.635 (1.445–1.850) < 0.001
FIGO stage
 INOS 39 (0.395) Reference   Reference  
 IANOS 94 (0.952) 0.432 (0.171–1.087) 0.075 0.543 (0.215–1.371) 0.196
 IA1 1017 (10.297) 0.115 (0.054–0.243) < 0.001 0.164 (0.077–0.350) < 0.001
 IA2 357 (3.615) 0.208 (0.094–0.464) < 0.001 0.344 (0.154–0.768) 0.009
 IB1 2774 (28.088) 0.320 (0.164–0.624) 0.001 0.547 (0.280–1.069) 0.078
 IB2 713 (7.220) 0.869 (0.443–1.704) 0.682 0.912 (0.463–1.796) 0.789
 IIA1 181 (1.833) 0.941 (0.454–1.950) 0.870 1.287 (0.620–2.671) 0.498
 IIA2 261 (2.643) 1.515 (0.760–3.019) 0.238 1.369 (0.684–2.739) 0.375
 IIB 885 (8.961) 1.203 (0.618–2.342) 0.586 1.207 (0.618–2.358) 0.581
 IIINOS 25 (0.253) 2.503 (1.055–5.942) 0.037 2.625 (1.104–6.244) 0.029
 IIIA 102 (1.033) 2.504 (1.224–5.123) 0.012 1.993 (0.971–4.093) 0.060
 IIIB 2257 (22.853) 1.911 (0.991–3.686) 0.053 2.351 (1.208–4.574) 0.012
 IVA 180 (1.823) 4.793 (2.437–9.426) < 0.001 4.117 (2.082–8.141) < 0.001
 IVB 991 (10.034) 5.665 (2.934–10.936) < 0.001 3.661 (1.473–9.104) 0.005
Cancer cells in lymph nodes
 Yes 2634 (26.671) Reference   Reference  
 No 7242 (73.329) 0.318 (0.294–0.344) < 0.001 1.018 (0.912–1.137) 0.750
Metastasis
 Yes 1009 (10.217) Reference   Reference  
 No 8867 (89.783) 0.164 (0.150–0.179) < 0.001 0.707 (0.378–1.320) 0.276
Primary site surgery
 Yes 6462 (65.431) Reference   Reference  
 No/Unknown 3414 (34.569) 4.729 (4.355–5.135) < 0.001 1.476 (1.305–1.670) < 0.001
Regional lymph node surgery
 Yes 4932 (49.939) Reference   Reference  
 No/Unknown 4944 (50.061) 3.401 (3.114–3.716) < 0.001 1.691 (1.491–1.919) < 0.001
Radiotherapy
 Yes 5792 (58.647) Reference   Reference  
 No/Unknown 4084 (41.353) 0.397 (0.362–0.536) < 0.001 1.317 (1.171–1.482) < 0.001
Chemotherapy
 Yes 5122 (51.863) Reference   Reference  
 No/Unknown 4754 (48.137) 0.390 (0.358–0.426) < 0.001 1.714 (1.537–1.911) < 0.001