Variables | N (%) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | ||
Age at diagnosis, years old | |||||
  < 45 | 4057 (41.079) | Reference |  | Reference |  |
 45–59 | 3408 (34.508) | 1.588 (1.436–1.756) | < 0.001 | 1.110 (1.001–1.231) | 0.047 |
  ≥ 60 | 2411 (24.413) | 2.748 (2.491–3.031) | < 0.001 | 1.536 (1.380–1.709) | < 0.001 |
Race | |||||
 White | 7572 (76.671) | Reference |  | Reference |  |
 Black | 1204 (12.191) | 1.679 (1.513–1.863) | < 0.001 | 1.282 (1.152–1.426) | < 0.001 |
 Other | 1100 (11.138) | 1.062 (0.935–1.207) | 0.356 | 1.083 (0.952–1.232) | 0.226 |
Marital status at diagnosis | |||||
 Single | 3020 (30.579) | Reference |  | Reference |  |
 Married | 4544 (46.011) | 0.716 (0.652–0.787) | < 0.001 | 0.852 (0.773–0.940) | 0.001 |
 Other | 2312 (23.410) | 1.290 (1.169–1.424) | < 0.001 | 1.101 (0.992–1.223) | 0.072 |
Grade | |||||
 I | 1482 (15.006) | Reference |  | Reference |  |
 II | 4285 (43.388) | 2.546 (2.121–3.055) | < 0.001 | 1.374 (1.138–1.659) | 0.001 |
 III | 4109 (41.606) | 4.690 (3.924–5.604) | < 0.001 | 1.732 (1.436–2.088) | < 0.001 |
Histology | |||||
 SCC | 6363 (64.429) | Reference |  | Reference |  |
 AC | 3113 (31.521) | 0.633 (0.576–0.696) | < 0.001 | 1.076 (0.974–1.189) | 0.150 |
 Other | 400 (4.050) | 2.585 (2.242–2.980) | < 0.001 | 1.757 (1.512–2.042) | < 0.001 |
Tumor size | |||||
  < 4 cm | 5315 (53.817) | Reference |  | Reference |  |
  ≥ 4 cm | 4561 (46.183) | 5.084 (4.629–5.583) | < 0.001 | 1.635 (1.445–1.850) | < 0.001 |
FIGO stage | |||||
 INOS | 39 (0.395) | Reference |  | Reference |  |
 IANOS | 94 (0.952) | 0.432 (0.171–1.087) | 0.075 | 0.543 (0.215–1.371) | 0.196 |
 IA1 | 1017 (10.297) | 0.115 (0.054–0.243) | < 0.001 | 0.164 (0.077–0.350) | < 0.001 |
 IA2 | 357 (3.615) | 0.208 (0.094–0.464) | < 0.001 | 0.344 (0.154–0.768) | 0.009 |
 IB1 | 2774 (28.088) | 0.320 (0.164–0.624) | 0.001 | 0.547 (0.280–1.069) | 0.078 |
 IB2 | 713 (7.220) | 0.869 (0.443–1.704) | 0.682 | 0.912 (0.463–1.796) | 0.789 |
 IIA1 | 181 (1.833) | 0.941 (0.454–1.950) | 0.870 | 1.287 (0.620–2.671) | 0.498 |
 IIA2 | 261 (2.643) | 1.515 (0.760–3.019) | 0.238 | 1.369 (0.684–2.739) | 0.375 |
 IIB | 885 (8.961) | 1.203 (0.618–2.342) | 0.586 | 1.207 (0.618–2.358) | 0.581 |
 IIINOS | 25 (0.253) | 2.503 (1.055–5.942) | 0.037 | 2.625 (1.104–6.244) | 0.029 |
 IIIA | 102 (1.033) | 2.504 (1.224–5.123) | 0.012 | 1.993 (0.971–4.093) | 0.060 |
 IIIB | 2257 (22.853) | 1.911 (0.991–3.686) | 0.053 | 2.351 (1.208–4.574) | 0.012 |
 IVA | 180 (1.823) | 4.793 (2.437–9.426) | < 0.001 | 4.117 (2.082–8.141) | < 0.001 |
 IVB | 991 (10.034) | 5.665 (2.934–10.936) | < 0.001 | 3.661 (1.473–9.104) | 0.005 |
Cancer cells in lymph nodes | |||||
 Yes | 2634 (26.671) | Reference |  | Reference |  |
 No | 7242 (73.329) | 0.318 (0.294–0.344) | < 0.001 | 1.018 (0.912–1.137) | 0.750 |
Metastasis | |||||
 Yes | 1009 (10.217) | Reference |  | Reference |  |
 No | 8867 (89.783) | 0.164 (0.150–0.179) | < 0.001 | 0.707 (0.378–1.320) | 0.276 |
Primary site surgery | |||||
 Yes | 6462 (65.431) | Reference |  | Reference |  |
 No/Unknown | 3414 (34.569) | 4.729 (4.355–5.135) | < 0.001 | 1.476 (1.305–1.670) | < 0.001 |
Regional lymph node surgery | |||||
 Yes | 4932 (49.939) | Reference |  | Reference |  |
 No/Unknown | 4944 (50.061) | 3.401 (3.114–3.716) | < 0.001 | 1.691 (1.491–1.919) | < 0.001 |
Radiotherapy | |||||
 Yes | 5792 (58.647) | Reference |  | Reference |  |
 No/Unknown | 4084 (41.353) | 0.397 (0.362–0.536) | < 0.001 | 1.317 (1.171–1.482) | < 0.001 |
Chemotherapy | |||||
 Yes | 5122 (51.863) | Reference |  | Reference |  |
 No/Unknown | 4754 (48.137) | 0.390 (0.358–0.426) | < 0.001 | 1.714 (1.537–1.911) | < 0.001 |