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Table 1 Baseline characteristics, and results of univariate and multivariate Cox regression analysis

From: Calculating the overall survival probability in patients with cervical cancer: a nomogram and decision curve analysis-based study

Variables

N (%)

Univariate analysis

Multivariate analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Age at diagnosis, years old

  < 45

4057 (41.079)

Reference

 

Reference

 

 45–59

3408 (34.508)

1.588 (1.436–1.756)

< 0.001

1.110 (1.001–1.231)

0.047

  ≥ 60

2411 (24.413)

2.748 (2.491–3.031)

< 0.001

1.536 (1.380–1.709)

< 0.001

Race

 White

7572 (76.671)

Reference

 

Reference

 

 Black

1204 (12.191)

1.679 (1.513–1.863)

< 0.001

1.282 (1.152–1.426)

< 0.001

 Other

1100 (11.138)

1.062 (0.935–1.207)

0.356

1.083 (0.952–1.232)

0.226

Marital status at diagnosis

 Single

3020 (30.579)

Reference

 

Reference

 

 Married

4544 (46.011)

0.716 (0.652–0.787)

< 0.001

0.852 (0.773–0.940)

0.001

 Other

2312 (23.410)

1.290 (1.169–1.424)

< 0.001

1.101 (0.992–1.223)

0.072

Grade

 I

1482 (15.006)

Reference

 

Reference

 

 II

4285 (43.388)

2.546 (2.121–3.055)

< 0.001

1.374 (1.138–1.659)

0.001

 III

4109 (41.606)

4.690 (3.924–5.604)

< 0.001

1.732 (1.436–2.088)

< 0.001

Histology

 SCC

6363 (64.429)

Reference

 

Reference

 

 AC

3113 (31.521)

0.633 (0.576–0.696)

< 0.001

1.076 (0.974–1.189)

0.150

 Other

400 (4.050)

2.585 (2.242–2.980)

< 0.001

1.757 (1.512–2.042)

< 0.001

Tumor size

  < 4 cm

5315 (53.817)

Reference

 

Reference

 

  ≥ 4 cm

4561 (46.183)

5.084 (4.629–5.583)

< 0.001

1.635 (1.445–1.850)

< 0.001

FIGO stage

 INOS

39 (0.395)

Reference

 

Reference

 

 IANOS

94 (0.952)

0.432 (0.171–1.087)

0.075

0.543 (0.215–1.371)

0.196

 IA1

1017 (10.297)

0.115 (0.054–0.243)

< 0.001

0.164 (0.077–0.350)

< 0.001

 IA2

357 (3.615)

0.208 (0.094–0.464)

< 0.001

0.344 (0.154–0.768)

0.009

 IB1

2774 (28.088)

0.320 (0.164–0.624)

0.001

0.547 (0.280–1.069)

0.078

 IB2

713 (7.220)

0.869 (0.443–1.704)

0.682

0.912 (0.463–1.796)

0.789

 IIA1

181 (1.833)

0.941 (0.454–1.950)

0.870

1.287 (0.620–2.671)

0.498

 IIA2

261 (2.643)

1.515 (0.760–3.019)

0.238

1.369 (0.684–2.739)

0.375

 IIB

885 (8.961)

1.203 (0.618–2.342)

0.586

1.207 (0.618–2.358)

0.581

 IIINOS

25 (0.253)

2.503 (1.055–5.942)

0.037

2.625 (1.104–6.244)

0.029

 IIIA

102 (1.033)

2.504 (1.224–5.123)

0.012

1.993 (0.971–4.093)

0.060

 IIIB

2257 (22.853)

1.911 (0.991–3.686)

0.053

2.351 (1.208–4.574)

0.012

 IVA

180 (1.823)

4.793 (2.437–9.426)

< 0.001

4.117 (2.082–8.141)

< 0.001

 IVB

991 (10.034)

5.665 (2.934–10.936)

< 0.001

3.661 (1.473–9.104)

0.005

Cancer cells in lymph nodes

 Yes

2634 (26.671)

Reference

 

Reference

 

 No

7242 (73.329)

0.318 (0.294–0.344)

< 0.001

1.018 (0.912–1.137)

0.750

Metastasis

 Yes

1009 (10.217)

Reference

 

Reference

 

 No

8867 (89.783)

0.164 (0.150–0.179)

< 0.001

0.707 (0.378–1.320)

0.276

Primary site surgery

 Yes

6462 (65.431)

Reference

 

Reference

 

 No/Unknown

3414 (34.569)

4.729 (4.355–5.135)

< 0.001

1.476 (1.305–1.670)

< 0.001

Regional lymph node surgery

 Yes

4932 (49.939)

Reference

 

Reference

 

 No/Unknown

4944 (50.061)

3.401 (3.114–3.716)

< 0.001

1.691 (1.491–1.919)

< 0.001

Radiotherapy

 Yes

5792 (58.647)

Reference

 

Reference

 

 No/Unknown

4084 (41.353)

0.397 (0.362–0.536)

< 0.001

1.317 (1.171–1.482)

< 0.001

Chemotherapy

 Yes

5122 (51.863)

Reference

 

Reference

 

 No/Unknown

4754 (48.137)

0.390 (0.358–0.426)

< 0.001

1.714 (1.537–1.911)

< 0.001