Skip to main content

Table 1 Characteristics of the included studies

From: Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

First author Year Country HOX protein Expression Sample size
(high/low)
Cut-off value Survival Survival analysis HR availability NOS score
Sha et al. [15] 2013 China HOXB9 Downregulated 190 (86/104) IS:4 OS U, M Text 7
Wang et al. [16] 2015 China HOXD10 Downregulated 436 (242/194) IS:4 OS U Kaplan-Meier curves 7
Peng et al. [17] 2018 China HOXA5 Downregulated 81 (29/52) IS:4 OS U, M Text 8
Wu et al. [18] 2019 China HOXA5 Downregulated 124 (60/64) median value OS, DFS U Kaplan-Meier curves 7
Sentani et al. [19] 2012 Japan HOXA10 Upregulated 749 (221/528) percentage of stained cancer cells = 10% OS U, M Text 7
Han et al. [22] 2013 China HOXA13 Upregulated 132 (103/29) IS:3 OS, DFS U, M Text 7
Lim et al. [20] 2013 Korea HOXA10 Upregulated 57 (29/28) compare to the staining smooth muscle OS U Kaplan-Meier curves 7
Zhang et al. [24] 2013 China HOXC6 Upregulated 161 (76/85) IS:2 OS U Kaplan-Meier curves 8
Han et al. [21] 2015 China HOXA10 Upregulated 264 (159/105) IS:2 OS, DFS U, M Text 6
Tu et al. [25] 2015 China HOXB7 Upregulated 96 (66/30) IS:2 OS, DFS U, M Text 8
Yuan et al. [27] 2016 China HOXA1 Upregulated 264 (144/120) IS:3 OS, DFS U Text 6
He et al. [26] 2017 China HOXB7 Upregulated 330 (195/135) IS:4 OS U Kaplan-Meier curves 8
Ma et al. [28] 2017 China HOXA9 Upregulated 128 (88/40) IS:4 OS U, M Text 8
Han et al. [23] 2018 China HOXA13 Upregulated 264 (186/78) IS:3 OS, DFS U, M Text 6
Peng et al. [29] 2018 China HOXC9 Upregulated 95 (68/27) IS:4 OS U, M Text 7
Yao et al. [30] 2018 China HOXC10 Upregulated 73 (38/35) IS:4 OS U, M Text 7
Liu et al. [31] 2019 China HOXD4 Upregulated 127 (68/59) IS:7 OS U, M Text 7
Wang et al. [32] 2019 China HOXA11 Upregulated 114 (58/56) IOD/Area = 0.31 OS U, M Text 6
Zhu et al. [33] 2019 China HOXD9 Upregulated 90 (55/35) IS:3 OS U Kaplan-Meier curves 6
  1. OS Overall survival, DFS Disease free survival, U Univariate analysis, M Multivariate analysis, IS Immunostaining score, IOD Integrated option density, NOS Newcastle-Ottawa Scale