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Table 1 Relationship between cell-in-cell structures and clinicopathologic features in early-stage oral tongue cancer

From: Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer

Variable

Total

Cell-in-cell

P value of chi-square test

None

One or more

N = 308

N = 108 N (%)

N = 200 N (%)

 

Age

   

0.397

  ≤ 60

128

41 (32.0)

87 (68.0)

 

  > 60

180

67 (37.2)

113 (62.8)

 

Gender

   

>  0.999

 Male

164

58 (35.4)

106 (64.6)

 

 Female

144

50 (34.7)

94 (65.3)

 

cTNM stage

   

0.113

 T1N0M0

123

50 (40.7)

73 (59.3)

 

 T2N0M0

185

58 (31.4)

127 (68.6)

 

Grade (WHO)

   

0.031

 Well differentiated

104

46 (44.2)

58 (55.8)

 

 Moderately differentiated

130

36 (27.7)

94 (72.3)

 

 Poorly differentiated

74

26 (35.1)

48 (64.9)

 

Tumor budding

   

0.007

 Low (< 5 buds)

212

85 (40.1)

127 (59.9)

 

 High (≥5 buds)

98

23 (24.0)

73 (76.0)

 

Depth of invasion

   

< 0.001

 Superficial (< 4 mm)

113

61 (54.0)

52 (46.0)

 

 Deep (≥4 mm)

195

47 (24.1)

148 (75.9)

 

Worst pattern of invasion

   

< 0.001

 Cohesive

77

41 (53.2)

36 (46.8)

 

 Invasive

231

67 (29.0)

164 (71.0)

 

Tumor-stroma ratio

   

0.001

 Low

220

90 (40.9)

130 (59.1)

 

 High

88

18 (20.5)

70 (79.5)

 

Perineural invasion

   

0.010

 Absent

267

101 (37.8)

166 (62.2)

 

 Present

41

7 (17.1)

34 (82.9)