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Table 1 Relationship between cell-in-cell structures and clinicopathologic features in early-stage oral tongue cancer

From: Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer

Variable Total Cell-in-cell P value of chi-square test
None One or more
N = 308 N = 108 N (%) N = 200 N (%)  
Age     0.397
  ≤ 60 128 41 (32.0) 87 (68.0)  
  > 60 180 67 (37.2) 113 (62.8)  
Gender     >  0.999
 Male 164 58 (35.4) 106 (64.6)  
 Female 144 50 (34.7) 94 (65.3)  
cTNM stage     0.113
 T1N0M0 123 50 (40.7) 73 (59.3)  
 T2N0M0 185 58 (31.4) 127 (68.6)  
Grade (WHO)     0.031
 Well differentiated 104 46 (44.2) 58 (55.8)  
 Moderately differentiated 130 36 (27.7) 94 (72.3)  
 Poorly differentiated 74 26 (35.1) 48 (64.9)  
Tumor budding     0.007
 Low (< 5 buds) 212 85 (40.1) 127 (59.9)  
 High (≥5 buds) 98 23 (24.0) 73 (76.0)  
Depth of invasion     < 0.001
 Superficial (< 4 mm) 113 61 (54.0) 52 (46.0)  
 Deep (≥4 mm) 195 47 (24.1) 148 (75.9)  
Worst pattern of invasion     < 0.001
 Cohesive 77 41 (53.2) 36 (46.8)  
 Invasive 231 67 (29.0) 164 (71.0)  
Tumor-stroma ratio     0.001
 Low 220 90 (40.9) 130 (59.1)  
 High 88 18 (20.5) 70 (79.5)  
Perineural invasion     0.010
 Absent 267 101 (37.8) 166 (62.2)  
 Present 41 7 (17.1) 34 (82.9)