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Table 1 Correlations between clinicopathological characteristics of patients and LNM in the training and validation sets

From: A predictive nomogram for lymph node metastasis of incidental gallbladder cancer: a SEER population-based study

Characteristics Training Cohort    Validation set   
  LNM- LNM+ P value LNM- LNM+ P value
Median number of retrieved LN (IQR) 2 (1–5) / 2 (1–4) /
Age
  ≤ 60 103 (29.0%) 54 (26.3%) 0.561 40 (27.0%) 21 (23.9%) 0.702
 >60 252 (71.0%) 151 (73.7%)   108 (73.0%) 67 (76.1%)  
Gender
 Male 112 (31.5%) 52 (25.3%) 0.121 46 (31.1%) 18 (20.5%) 0.076
 Female 243 (68.5%) 153 (74.6%)   102 (68.9%) 70 (79.5%)  
Race
 White 249 (70.1%) 157 (76.6%) 0.214 108 (73.0%) 66 (75.0%) 0.456
 Black 50 (14.1%) 20 (9.8%)   19 (12.8%) 14 (15.9%)  
 Others 56 (15.8%) 28 (13.7%)   21 (14.2%) 8 (9.1%)  
Histology
 Adenocarcinoma 346 (97.5%) 203 (99.0%) 0.343* 147 (99.3%) 88 (100.0%) 0.999*
 Squamous cell carcinoma 9 (2.5%) 2 (1.0%)   1 (0.7%) 0 (0.0%)  
Grade
 Well differentiated 87 (24.5%) 26 (12.7%) < 0.001 39 (26.4%) 11 (12.5%) 0.008
 Moderately differentiated 181 (51.0%) 96 (46.8%)   71 (48.0%) 40 (45.5%)  
 Poorly/un- differentiated 87 (24.5%) 83 (40.5%)   38 (25.7%) 37 (42.0%)  
T stage
 T1a 38 (10.7%) 2 (1.0%) < 0.001 15 (10.1%) 2 (2.3%) < 0.001
 T1b 75 (21.1%) 8 (3.9%)   29 (19.6%) 5 (5.7%)  
 T2 242 (68.2%) 195 (95.1%)   104 (70.3%) 81 (92.0%)  
Tumor size
  ≤ 1 cm 67 (18.9%) 10 (4.9%) < 0.001 34 (23.0%) 5 (5.7%) 0.005
 >1 cm 288 (81.1%) 195 (95.1%)   114 (77.0%) 21 (94.3%)  
  1. LNM lymph node metastasis; IQR interquartile rage; * P value is derived from Fisher’s exact test; other P values are derived from Pearson’s chi-square test