Table 1 Baseline Demographics and Disease Characteristics
Total Study Cohort(n = 71) | Subset of Subjects with Pretreatment Tissue Biopsies(n = 47) | Remaining Subjects(n = 24) | P-value | |
|---|---|---|---|---|
Age (years) | 0.9466 | |||
Mean (SD) | 62.54 (10.0) | 62.43 (9.2) | 62.75 (11.6) | |
Median | 62 | 62 | 61.5 | |
Age, n(%) | 0.8108 | |||
< 70 | 52 (73) | 34 (72) | 18 (75) | |
> = 70 | 19 (27) | 13 (28) | 6 (25) | |
Sex, n(%) | 0.5282 | |||
Female | 26 (37) | 16 (34) | 10 (42) | |
Male | 45 (63) | 31 (66) | 14 (58) | |
ECOG Status, n(%) | 0.1672 | |||
0 | 22 (31) | 17 (36) | 5 (21) | |
1 | 44 (62) | 28 (60) | 16 (67) | |
2 | 3 (4) | 2 (4) | 1 (4) | |
3 | 2 (3) | – | 2 (8) | |
Stage, n(%) | 0.3136 | |||
IIIA | 4 (6) | 2 (4) | 2 (8) | |
IIIB | 8 (11) | 7 (15) | 1 (4) | |
IV | 59 (83) | 38 (81) | 21 (88) | |
Histology, n(%) | 0.4137 | |||
Adenocarcinoma | 68 (96) | 45 (96) | 23 (96) | |
Adenocarcinoma|Large cell carcinomaa | 1 (1) | – | 1 (4) | |
Adenocarcinoma|Squamous cell carcinomaa | 2 (3) | 2 (4) | – | |
1 L Therapy Received, n(%) | 0.8582 | |||
Chemotherapy Onlyb | 31 (44) | 21 (45) | 10 (42) | |
Chemo+Radiationc | 25 (35) | 17 (36) | 8 (33) | |
Chemo+Targetedd | 9 (13) | 6 (13) | 3 (13) | |
Chemo+Radiation+Targetedd | 6 (8) | 3 (6) | 3 (13) | |
Smoking Status, n(%) | 0.8495 | |||
Never Smoker | 11 (15) | 6 (13) | 5 (21) | |
Quit more than 5 years ago | 9 (13) | 6 (13) | 3 (13) | |
Quit less than 5 years ago | 9 (13) | 6 (13) | 3 (13) | |
Current Smoker | 42 (59) | 29 (62) | 13 (54) |