From: Myxoid stroma is associated with postoperative relapse in patients with stage II colon cancer
 | RFS | OS | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Predictor | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
 | HR | 95%CI | p value | HR | 95%CI | p value | HR | 95%CI | p value | HR | 95%CI | p value |
Gender | ||||||||||||
 Male | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 Female | 0.71 | 0.298–1.697 | 0.44 |  |  |  | 0.67 | 0.247–1.808 | 0.43 |  |  |  |
Age | ||||||||||||
  < 70 yr | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
  ≥ 70 yr | 1.05 | 0.446–2.445 | 0.92 |  |  |  | 2.43 | 0.792–7.465 | 0.12 |  |  |  |
Serum CEA level | ||||||||||||
  < 5 | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
  ≥ 5 | 1.41 | 0.609–3.264 | 0.42 |  |  |  | 0.91 | 0.337–2.465 | 0.86 |  |  |  |
Serum CA19–9 level | ||||||||||||
  < 37.5 | 1 |  |  |  |  |  | 1.00 |  |  | 1 |  |  |
  ≥ 37.5 | 1.73 | 0.638–4.693 | 0.28 |  |  |  | 3.11 | 1.149–8.428 | 0.026 | 0.62 | 0.355–1.096 | 0.10 |
Tumor location | ||||||||||||
 Right | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 Left | 1.10 | 0.478–2.541 | 0.82 |  |  |  | 0.58 | 0.214–1.565 | 0.28 |  |  |  |
Differentiation | ||||||||||||
 Well, moderately, pap | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 por, muc | 0.36 | 0.049–2.698 | 0.32 |  |  |  | 1.18 | 0.268–5.198 | 0.83 |  |  |  |
Tumor size | ||||||||||||
  ≤ 5 | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
  > 5 | 1.22 | 0.536–2.789 | 0.63 |  |  |  | 0.80 | 0.310–2.080 | 0.65 |  |  |  |
Tumor depth | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 pT3 | 1 |  |  | 1 |  |  | 1.00 |  |  | 1 |  |  |
 pT4 | 2.52 | 0.986–6.452 | 0.054 | 1.75 | 0.594–5.153 | 0.31 | 3.66 | 1.352–9.922 | 0.011 | 0.84 | 0.429–1.651 | 0.62 |
Lymphatic invasion | ||||||||||||
 Absent | 1 |  |  |  |  |  | 1.00 |  |  | 1 |  |  |
 Present | 1.03 | 0.398–2.264 | 0.91 |  |  |  | 2.48 | 0.941–6.515 | 0.07 | 0.91 | 0.519–1.596 | 0.74 |
Vessel invasion | ||||||||||||
 Absent | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 Present | 1.65 | 0.674–4.056 | 0.27 |  |  |  | 1.09 | 0.416–2.875 | 0.86 |  |  |  |
Tumor budding | ||||||||||||
 Grade 1 | 1 |  |  | 1 |  |  | 1.00 |  |  | 1 |  |  |
 Grade 2,3 | 9.00 | 3.042–26.624 | < 0.001 | 4.11 | 1.301–13.002 | 0.02 | 6.18 | 2.015–18.977 | 0.001 | 1.94 | 1.020–3.668 | 0.043 |
Surgical margin | ||||||||||||
 Absent | 1 |  |  | 1 |  |  | 1.00 |  |  | 1 |  |  |
 Present | 4.69 | 1.088–20.207 | 0.038 | 4.33 | 0.769–24.343 | 0.10 | 6.52 | 1.465–28.999 | 0.014 | 0.56 | 0.219–1.411 | 0.22 |
Lymph node yield | ||||||||||||
 12 or more | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 Less than 12 | 1.03 | 0.420–2.524 | 0.95 |  |  |  | 1.10 | 3.87–3.131 | 0.86 |  |  |  |
Obstruction/perforation | ||||||||||||
 Absent | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 Present | 1.39 | 0.325–5.945 | 0.66 |  |  |  | 1.85 | 0.423–8.110 | 0.41 |  |  |  |
Operation | ||||||||||||
 Laparotomy | 1 |  |  |  |  |  | 1.00 |  |  |  |  |  |
 Laparoscopic surgery | 1.26 | 0.542–2.906 | 0.60 |  |  |  | 1.13 | 0.427–2.972 | 0.81 |  |  |  |
Glucose tolerance | ||||||||||||
 Normal | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Abnormality | 1.88 | 0.636–5.556 | 0.25 |  |  |  | 1.92 | 0.550–6.677 | 0.31 |  |  |  |
Adjuvant chemotherapy | ||||||||||||
 No | 1 |  |  |  |  |  | 1 |  |  |  |  |  |
 Yes | 1.07 | 0.317–3.622 | 0.91 |  |  |  | 2.18 | 0.710–6.683 | 0.17 |  |  |  |
Myxoid stroma | ||||||||||||
 Absent | 1 |  |  | 1 |  |  | 1 |  |  | 1 |  |  |
 Present | 11.24 | 4.572–27.613 | < 0.001 | 6.80 | 2.579–17.911 | < 0.001 | 4.14 | 1.596–10.742 | 0.003 | 0.66 | 0.371–1.157 | 0.15 |