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Table 4 Uni- and multi-variate analyses using Cox proportional hazard regression models to identify to Clinicopathological characteristics related to relapse free survival and overall survival

From: Myxoid stroma is associated with postoperative relapse in patients with stage II colon cancer

 

RFS

OS

Predictor

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

 

HR

95%CI

p value

HR

95%CI

p value

HR

95%CI

p value

HR

95%CI

p value

Gender

 Male

1

     

1.00

     

 Female

0.71

0.298–1.697

0.44

   

0.67

0.247–1.808

0.43

   

Age

  < 70 yr

1

     

1.00

     

  ≥ 70 yr

1.05

0.446–2.445

0.92

   

2.43

0.792–7.465

0.12

   

Serum CEA level

  < 5

1

     

1.00

     

  ≥ 5

1.41

0.609–3.264

0.42

   

0.91

0.337–2.465

0.86

   

Serum CA19–9 level

  < 37.5

1

     

1.00

  

1

  

  ≥ 37.5

1.73

0.638–4.693

0.28

   

3.11

1.149–8.428

0.026

0.62

0.355–1.096

0.10

Tumor location

 Right

1

     

1.00

     

 Left

1.10

0.478–2.541

0.82

   

0.58

0.214–1.565

0.28

   

Differentiation

 Well, moderately, pap

1

     

1.00

     

 por, muc

0.36

0.049–2.698

0.32

   

1.18

0.268–5.198

0.83

   

Tumor size

  ≤ 5

1

     

1.00

     

  > 5

1.22

0.536–2.789

0.63

   

0.80

0.310–2.080

0.65

   

Tumor depth

            

 pT3

1

  

1

  

1.00

  

1

  

 pT4

2.52

0.986–6.452

0.054

1.75

0.594–5.153

0.31

3.66

1.352–9.922

0.011

0.84

0.429–1.651

0.62

Lymphatic invasion

 Absent

1

     

1.00

  

1

  

 Present

1.03

0.398–2.264

0.91

   

2.48

0.941–6.515

0.07

0.91

0.519–1.596

0.74

Vessel invasion

 Absent

1

     

1.00

     

 Present

1.65

0.674–4.056

0.27

   

1.09

0.416–2.875

0.86

   

Tumor budding

 Grade 1

1

  

1

  

1.00

  

1

  

 Grade 2,3

9.00

3.042–26.624

< 0.001

4.11

1.301–13.002

0.02

6.18

2.015–18.977

0.001

1.94

1.020–3.668

0.043

Surgical margin

 Absent

1

  

1

  

1.00

  

1

  

 Present

4.69

1.088–20.207

0.038

4.33

0.769–24.343

0.10

6.52

1.465–28.999

0.014

0.56

0.219–1.411

0.22

Lymph node yield

 12 or more

1

     

1.00

     

 Less than 12

1.03

0.420–2.524

0.95

   

1.10

3.87–3.131

0.86

   

Obstruction/perforation

 Absent

1

     

1.00

     

 Present

1.39

0.325–5.945

0.66

   

1.85

0.423–8.110

0.41

   

Operation

 Laparotomy

1

     

1.00

     

 Laparoscopic surgery

1.26

0.542–2.906

0.60

   

1.13

0.427–2.972

0.81

   

Glucose tolerance

 Normal

1

     

1

     

 Abnormality

1.88

0.636–5.556

0.25

   

1.92

0.550–6.677

0.31

   

Adjuvant chemotherapy

 No

1

     

1

     

 Yes

1.07

0.317–3.622

0.91

   

2.18

0.710–6.683

0.17

   

Myxoid stroma

 Absent

1

  

1

  

1

  

1

  

 Present

11.24

4.572–27.613

< 0.001

6.80

2.579–17.911

< 0.001

4.14

1.596–10.742

0.003

0.66

0.371–1.157

0.15