Skip to main content

Table 4 Uni- and multi-variate analyses using Cox proportional hazard regression models to identify to Clinicopathological characteristics related to relapse free survival and overall survival

From: Myxoid stroma is associated with postoperative relapse in patients with stage II colon cancer

  RFS OS
Predictor Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
  HR 95%CI p value HR 95%CI p value HR 95%CI p value HR 95%CI p value
Gender
 Male 1       1.00      
 Female 0.71 0.298–1.697 0.44     0.67 0.247–1.808 0.43    
Age
  < 70 yr 1       1.00      
  ≥ 70 yr 1.05 0.446–2.445 0.92     2.43 0.792–7.465 0.12    
Serum CEA level
  < 5 1       1.00      
  ≥ 5 1.41 0.609–3.264 0.42     0.91 0.337–2.465 0.86    
Serum CA19–9 level
  < 37.5 1       1.00    1   
  ≥ 37.5 1.73 0.638–4.693 0.28     3.11 1.149–8.428 0.026 0.62 0.355–1.096 0.10
Tumor location
 Right 1       1.00      
 Left 1.10 0.478–2.541 0.82     0.58 0.214–1.565 0.28    
Differentiation
 Well, moderately, pap 1       1.00      
 por, muc 0.36 0.049–2.698 0.32     1.18 0.268–5.198 0.83    
Tumor size
  ≤ 5 1       1.00      
  > 5 1.22 0.536–2.789 0.63     0.80 0.310–2.080 0.65    
Tumor depth             
 pT3 1    1    1.00    1   
 pT4 2.52 0.986–6.452 0.054 1.75 0.594–5.153 0.31 3.66 1.352–9.922 0.011 0.84 0.429–1.651 0.62
Lymphatic invasion
 Absent 1       1.00    1   
 Present 1.03 0.398–2.264 0.91     2.48 0.941–6.515 0.07 0.91 0.519–1.596 0.74
Vessel invasion
 Absent 1       1.00      
 Present 1.65 0.674–4.056 0.27     1.09 0.416–2.875 0.86    
Tumor budding
 Grade 1 1    1    1.00    1   
 Grade 2,3 9.00 3.042–26.624 < 0.001 4.11 1.301–13.002 0.02 6.18 2.015–18.977 0.001 1.94 1.020–3.668 0.043
Surgical margin
 Absent 1    1    1.00    1   
 Present 4.69 1.088–20.207 0.038 4.33 0.769–24.343 0.10 6.52 1.465–28.999 0.014 0.56 0.219–1.411 0.22
Lymph node yield
 12 or more 1       1.00      
 Less than 12 1.03 0.420–2.524 0.95     1.10 3.87–3.131 0.86    
Obstruction/perforation
 Absent 1       1.00      
 Present 1.39 0.325–5.945 0.66     1.85 0.423–8.110 0.41    
Operation
 Laparotomy 1       1.00      
 Laparoscopic surgery 1.26 0.542–2.906 0.60     1.13 0.427–2.972 0.81    
Glucose tolerance
 Normal 1       1      
 Abnormality 1.88 0.636–5.556 0.25     1.92 0.550–6.677 0.31    
Adjuvant chemotherapy
 No 1       1      
 Yes 1.07 0.317–3.622 0.91     2.18 0.710–6.683 0.17    
Myxoid stroma
 Absent 1    1    1    1   
 Present 11.24 4.572–27.613 < 0.001 6.80 2.579–17.911 < 0.001 4.14 1.596–10.742 0.003 0.66 0.371–1.157 0.15