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Table 3 Clinical characteristics and laboratory results at diagnosis of APL patients with or without DS

From: Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

Variable at diagnosis

All patients, (n = 17)

DS group, (n = 6)

Non-DS group, (n = 11)

P-value2

N.

%

Median (range)

N.

%

Median (range)

N.

%

Median (range)

Gender

         

0.64

 Female

10

58.8

 

3

50

 

7

63.6

  

 Male

7

41.2

 

3

50

 

4

36.4

  

Age, years

  

36.25 (17.42, 72.08)

  

38.37 (21, 59.33)

  

36.25 (38.33, 72.08)

0.40

 < 40

7

41.2

 

2

33.3

 

5

45.5

  

 ≥ 40

10

58.8

 

4

66.7

 

6

54.5

  

Leukocyte counts, ×109/L

  

2.4 (0.5, 83.5)

  

2.0 (1.6, 48.7)

  

1.6 (1.2, 83.5)

0.02*

 < 10

11

64.7

 

2

33.3

 

9

81.8

  

 ≥ 10

6

35.3

 

4

66.7

 

2

18.2

  

Platelet counts, ×109/L

  

36 (5, 110)

  

43 (39, 71)

  

28 (14, 110)

0.98

 < 40

10

58.8

 

3

50

 

7

63.6

  

 ≥ 40

7

41.2

 

3

50

 

4

36.4

  

Relapse-risk group1

         

0.10

 Low/Intermediate

11

64.7

 

2

33.3

 

9

81.8

  

 High

6

35.3

 

4

66.7

 

2

18.2

  

Fibrinogen (mg/dL)

  

152.7 (66, 400)

  

207.5 (77, 400)

  

146.7 (66, 390)

0.48

 < 170

8

50

 

3

50

 

5

50

  

 ≥ 170

8

50

 

3

50

 

5

50

  

 Unknown

1

 

 

1

  

Death during induction

         

0.10

 Yes

2

12.5

 

2

33.3

 

0

0

  

 No

15

87.5

 

4

66.7

 

11

100

  
  1. APL Acute promyelocytic leukemia, DS Differentiation syndrome
  2. 1Classification according to PETHEMA-GIMEMA criteria
  3. 2Fisher’s two-tailed exact test was used to compare categorical variables. Mann-Whitney U test was used to compare continuous variables
  4. * Indicate values statistically significant when P < .05