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Table 3 Clinical characteristics and laboratory results at diagnosis of APL patients with or without DS

From: Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

Variable at diagnosis All patients, (n = 17) DS group, (n = 6) Non-DS group, (n = 11) P-value2
N. % Median (range) N. % Median (range) N. % Median (range)
Gender           0.64
 Female 10 58.8   3 50   7 63.6   
 Male 7 41.2   3 50   4 36.4   
Age, years    36.25 (17.42, 72.08)    38.37 (21, 59.33)    36.25 (38.33, 72.08) 0.40
 < 40 7 41.2   2 33.3   5 45.5   
 ≥ 40 10 58.8   4 66.7   6 54.5   
Leukocyte counts, ×109/L    2.4 (0.5, 83.5)    2.0 (1.6, 48.7)    1.6 (1.2, 83.5) 0.02*
 < 10 11 64.7   2 33.3   9 81.8   
 ≥ 10 6 35.3   4 66.7   2 18.2   
Platelet counts, ×109/L    36 (5, 110)    43 (39, 71)    28 (14, 110) 0.98
 < 40 10 58.8   3 50   7 63.6   
 ≥ 40 7 41.2   3 50   4 36.4   
Relapse-risk group1           0.10
 Low/Intermediate 11 64.7   2 33.3   9 81.8   
 High 6 35.3   4 66.7   2 18.2   
Fibrinogen (mg/dL)    152.7 (66, 400)    207.5 (77, 400)    146.7 (66, 390) 0.48
 < 170 8 50   3 50   5 50   
 ≥ 170 8 50   3 50   5 50   
 Unknown 1    1   
Death during induction           0.10
 Yes 2 12.5   2 33.3   0 0   
 No 15 87.5   4 66.7   11 100   
  1. APL Acute promyelocytic leukemia, DS Differentiation syndrome
  2. 1Classification according to PETHEMA-GIMEMA criteria
  3. 2Fisher’s two-tailed exact test was used to compare categorical variables. Mann-Whitney U test was used to compare continuous variables
  4. * Indicate values statistically significant when P < .05
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