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Table 2 Clinical and laboratory variables in the groups of patients with low or high levels of IL-6 and IL-8 at diagnosis

From: Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

  IL-6 high
Median (range) [pg/mL]
Rb Pb IL-6 low
Median (range) [pg/mL]
Rb Pb IL-8 high
Median (range) [pg/mL]
Rb Pb IL-8 low
Median (range)
[pg/mL]
Rb Pb
Gendera
 Female (n = 10) 13.3 (9.8–16.0) 1.2 (0–5.0) 65.8 (41.4–147.1) 12.9 (2.6–25.9)
 Male (n = 7) 93.1 (6.8–580.1) 1.7 (0–3.6) 85.3 (34.1–285.1) 7.5 (3.3–19.6)
Age, years
 < 40 (n = 11) 13.3 (6.8–580.1) 0.39 0.38 2.7 (0–5.0) - 0.20 0.80 73.0 (34.1–147.1) 0.71 0.11 19.6 (34.1–147.1) 0.40 0.50
 ≥ 40 (n = 6) 17.6 (16.0–19.2) c c 0.73 (0–2.9) 0.31 0.54 126.1 (41.4–285.1) - 0.50 0.66 6.9 (2.6–20.8) 0.60 0.28
Leukocyte counts, × 109/L
 < 10 (n = 11) 13.3 (6.8–580.1) - 0.63 0.12 2.3 (0–5.0) - 0.31 0.54 66.5 (34.1–285.1) - 0.25 0.58 13.6 (3.3–25.9) - 0.82 0.04*
 ≥ 10 (n = 6) 93.1 (19.2–167.0) c c 0.8 (0–1.8) 0.91 0.25 102.8 (79.6–126.1) c c 12.9 (2.6–20.8) 0.50 0.66
Platelet counts, × 109/L
 < 40 (n = 10) 14.2 (6.8–580.1) 0.80 0.10 0.9 (0–5.0) 0.52 0.28 105.7 (34.1–147.1) 0.40 0.60 6.9 (2.6–25.9) 0.32 0.47
 ≥ 40 (n = 7) 14.7 (9.8–167.0) - 0.21 0.78 0.8 (0.6–1.8) - 0.50 0.66 65.8 (41.4–79.6) - 0.63 0.36 12.9 (7.5–20.8) 0.50 0.66
Relapse-risk groupe,a
 Low/Intermediate (n = 11) 13.3 (6.8–580.1) 2.3 (0–5.0) 66.5 (34.1–285.1) 13.6 (3.3–25.9)
 High (n = 6) 93.1 (19.2–167.0) 0.8 (0–1.8) 102.8 (79.6–126.1 12.9 (2.6–20.8)
Death during inductiond
 Yes (n = 2) 167.0 (167.0) 0.8 (0.8) 79.6 (79.6) 20.8 (20.8)
 No (n = 15) 13.8 (6.8–580.1)    1.76 (0–5.0)    75.9 (34.1–285.1)    7.5 (2.6–25.9)   
  1. a Nominal variable
  2. b Spearman’s R correlation considering a significance at p < .05 (*)
  3. c The number of data pairs are too small to stablish a correlation
  4. d Dichotomous variable
  5. e Classification according to PETHEMA-GIMEMA criteria
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