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Table 2 Clinical and laboratory variables in the groups of patients with low or high levels of IL-6 and IL-8 at diagnosis

From: Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

 

IL-6 high

Median (range) [pg/mL]

Rb

Pb

IL-6 low

Median (range) [pg/mL]

Rb

Pb

IL-8 high

Median (range) [pg/mL]

Rb

Pb

IL-8 low

Median (range)

[pg/mL]

Rb

Pb

Gendera

 Female (n = 10)

13.3 (9.8–16.0)

1.2 (0–5.0)

65.8 (41.4–147.1)

12.9 (2.6–25.9)

 Male (n = 7)

93.1 (6.8–580.1)

1.7 (0–3.6)

85.3 (34.1–285.1)

7.5 (3.3–19.6)

Age, years

 < 40 (n = 11)

13.3 (6.8–580.1)

0.39

0.38

2.7 (0–5.0)

- 0.20

0.80

73.0 (34.1–147.1)

0.71

0.11

19.6 (34.1–147.1)

0.40

0.50

 ≥ 40 (n = 6)

17.6 (16.0–19.2)

c

c

0.73 (0–2.9)

0.31

0.54

126.1 (41.4–285.1)

- 0.50

0.66

6.9 (2.6–20.8)

0.60

0.28

Leukocyte counts, × 109/L

 < 10 (n = 11)

13.3 (6.8–580.1)

- 0.63

0.12

2.3 (0–5.0)

- 0.31

0.54

66.5 (34.1–285.1)

- 0.25

0.58

13.6 (3.3–25.9)

- 0.82

0.04*

 ≥ 10 (n = 6)

93.1 (19.2–167.0)

c

c

0.8 (0–1.8)

0.91

0.25

102.8 (79.6–126.1)

c

c

12.9 (2.6–20.8)

0.50

0.66

Platelet counts, × 109/L

 < 40 (n = 10)

14.2 (6.8–580.1)

0.80

0.10

0.9 (0–5.0)

0.52

0.28

105.7 (34.1–147.1)

0.40

0.60

6.9 (2.6–25.9)

0.32

0.47

 ≥ 40 (n = 7)

14.7 (9.8–167.0)

- 0.21

0.78

0.8 (0.6–1.8)

- 0.50

0.66

65.8 (41.4–79.6)

- 0.63

0.36

12.9 (7.5–20.8)

0.50

0.66

Relapse-risk groupe,a

 Low/Intermediate (n = 11)

13.3 (6.8–580.1)

2.3 (0–5.0)

66.5 (34.1–285.1)

13.6 (3.3–25.9)

 High (n = 6)

93.1 (19.2–167.0)

0.8 (0–1.8)

102.8 (79.6–126.1

12.9 (2.6–20.8)

Death during inductiond

 Yes (n = 2)

167.0 (167.0)

0.8 (0.8)

79.6 (79.6)

20.8 (20.8)

 No (n = 15)

13.8 (6.8–580.1)

  

1.76 (0–5.0)

  

75.9 (34.1–285.1)

  

7.5 (2.6–25.9)

  
  1. a Nominal variable
  2. b Spearman’s R correlation considering a significance at p < .05 (*)
  3. c The number of data pairs are too small to stablish a correlation
  4. d Dichotomous variable
  5. e Classification according to PETHEMA-GIMEMA criteria