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Fig. 1 | BMC Cancer

Fig. 1

From: Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

Fig. 1

IL-6 and IL-8 plasma levels in APL-DS patients during ATRA and anthracyclines treatment. a The comparison of the interleukin (IL) -6 plasma levels between patients with APL treated with all-trans retinoic acid (ATRA) and anthracyclines who developed (DS-group; n = 6) or not (non-DS group; n = 11) the differentiation syndrome (DS) were unchanged. b ATRA and anthracyclines significantly reduced the IL-8 levels regardless of the DS development (D7 vs. D0 of DS and non-DS groups combined together, p = 0.002 – Friedman’s test, followed by Dunn’s multiple comparison post-test). The IL-6 (c) and IL-8 (d) D3/D0 and D7/D0 ratios did not differ between DS- and non-DS patients with APL. The horizontal lines represent the median of cytokine plasma concentration in DS- (blue) and non-DS (black) groups

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