Fig. 3

Overview of the approach for defining NHR expression loss in a subset of tumors. a Of the 53 NHRs with unique ENSG identifiers [1], 47 were present among the pool of 35,308 expressed genes. Filtering steps were performed in parallel for both nuclear hormone receptors and all other genes (see Methods). b Histogram of mRNA expression data for PGR (Progesterone receptor) in 542 endometrial tumors derived from TCGA (blue). Expression of PGR in 35 adjacent normal endometrial tissues is represented by the dotted line. The boundary (B) is the point 2 standard deviations below the mean of the normal tissue and defines the classification boundary between low and high expression in tumors. μ_L represents the mean of the group below the boundary, and μ_H reflects the mean of the group of tumors above the boundary. c Distribution of the ∆μ statistic across 6536 genes (peach) and across 21 NHRs (blue)