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Table 1 Patient characteristics by antipsychotic use at cohort entry for all patients and by diagnosis of a severe mental illness

From: Post-diagnostic antipsychotic use and cancer mortality: a population based cohort study

  All breast cancer patients Breast cancer patients with severe mental illness
Antipsychotic user a Antipsychotic non-user Antipsychotic user a Antipsychotic non-user
Total 537 (2.3) 23,158 (97.7) 164 (49.1) 170 (50.9)
Year, n (%)
 1998–2002 129 (24.0) 5616 (24.3) 36 (22.0) 35 (20.6)
 2003–2007 203 (37.8) 8592 (37.1) 60 (36.6) 59 (34.7)
 2008–2012 205 (38.2) 8950 (38.6) 68 (41.5) 76 (44.7)
Age, mean (SD) 64.7 (14) 62 (14) 62.1 (11.5) 65.4 (14.2)
 0–49 93 (17.3) 4927 (21.3) 20 (12.2) 28 (16.5)
 50–59 118 (22.0) 5799 (25.0) 52 (31.7) 35 (20.6)
 60–69 138 (25.7) 5783 (25.0) 51 (31.1) 42 (24.7)
 70–79 188 (35.0) 6649 (28.7) 41 (25.0) 65 (38.2)
Deprivation, n (%)
 1 (Least Deprived) 98 (18.2) 5927 (25.6) 31 (18.9) 33 (19.4)
 2 121 (22.5) 5974 (25.8) 28 (17.1) 51 (30.0)
 3 116 (21.6) 4767 (20.6) 33 (20.1) 34 (20.0)
 4 103 (19.2) 3848 (16.6) 32 (19.5) 32 (18.8)
 5 (Most Deprived) 99 (18.4) 2633 (11.4) 40 (24.4) 20 (11.8)
Breast cancer treatment, n (%)
 Surgery 350 (65.2) 18,947 (81.8) 116 (70.7) 122 (71.8)
 Radiotherapy 131 (24.4) 8297 (35.8) 45 (27.4) 46 (27.1)
 Chemotherapy 149 (27.7) 6658 (28.8) 37 (22.6) 48 (28.2)
 Tamoxifen 211 (39.3) 9902 (42.8) 59 (36.0) 79 (46.5)
 Aromatase inhibitors 152 (28.3) 4854 (21.0) 54 (32.9) 45 (26.5)
Grade, n (%)
 1 67 (12.5) 3717 (16.1) 25 (15.2) 28 (16.5)
 2 235 (43.8) 10,057 (43.4) 73 (44.5) 72 (42.4)
 3 140 (26.1) 6907 (29.8) 41 (25.0) 52 (30.6)
 4 2 (0.4) 17 (0.1) 0 0
 Missing 93 (17.3) 2460 (10.6) 25 (15.2) 18 (10.6)
Stage, n (%)
 1 78 (14.5) 4714 (20.4) 31 (18.9) 31 (18.2)
 2 89 (16.6) 3844 (16.6) 29 (17.7) 33 (19.4)
 3 13 (2.4) 733 (3.2) * *
 4 17 (3.2) 291 (1.3) * *
 Missing 340 (63.3) 13,576 (58.6) 95 (57.9) 93 (54.7)
Comorbidities, n (%)
 Chronic pulmonary disease 98 (18.2) 3741 (16.2) 25 (15.2) 36 (21.2)
 Diabetes 65 (12.1) 1440 (6.2) 16 (9.8) 16 (9.4)
 Renal disease 41 (7.6) 1052 (4.5) 28 (17.1) 14 (8.2)
 Cerebrovascular disease 24 (4.5) 813 (3.5) 9 (5.5) 10 (5.9)
 Peptic ulcer disease 16 (3.0) 492 (2.1) 4 (2.4) 5 (2.9)
 Serious mental illness 164 (30.5) 170 (0.7) 164 (100.0) 170 (100.0)
Statin use, n (%) 92 (17.1) 3454 (14.9) 38 (23.2) 29 (17.1)
Aspirin use, n (%) 97 (18.1) 2901 (12.5) 29 (17.7) 31 (18.2)
HRT use, n (%) 151 (28.1) 7571 (32.7) 56 (34.1) 62 (36.5)
Smoking status, n (%)
 Current 264 (55.5) 12,705 (61.3) 71 (47.3) 80 (53.0)
 Ex 92 (19.3) 4593 (22.2) 28 (18.7) 31 (20.5)
 Non-smoker 120 (25.2) 3431 (16.6) 51 (34.0) 40 (26.5)
 Missing 61 2429 14 19
BMI, mean (SD) 28.1 (6.1) 27.0 (5.5) 29.4 (5.9) 27.1 (6.1)
  1. a Antisychotic use is defined as use of any antipsychotic within one year of breast cancer diagnosis
  2. *Number suppressed due to small cell counts (< 5)