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Table 2 Association between parental occupational exposure to pesticides and risk of childhood cancer in the Swiss National Cohort; major diagnostic groups only

From: Parental occupational exposure to pesticides and risk of childhood cancer in Switzerland: a census-based cohort study

   Paternal exposure Maternal exposure
Outcome Likelihood of
Exposure
Cases Partially adjusted model1 Fully adjusted model2 Cases Partially adjusted model1 Fully adjusted model2
   n HR [95%CI] HR [95%CI] n HR [95%CI] HR [95%CI]
Any cancer Minimal 1559 1 1 1808 1 1
High 112 0.95 [0.79–1.16] 1.14 [0.91–1.43] 49 1.00 [0.75–1.33] 1.13 [0.82–1.56]
Leukaemia Minimal 438 1 1 515 1 1
High 24 0.73 [0.49–1.10] 0.79 [0.48–1.29] 9 0.66 [0.34–1.27] 0.66 [0.29–1.49]
Lymphoma Minimal 297 1 1 333 1 1
High 21 0.92 [0.59–1.43] 1.06 [0.63–1.78] 9 0.96 [0.49–1.86] 1.18 [0.57–2.44]
CNST Minimal 345 1 1 405 1 1
High 20 0.78 [0.50–1.22] 0.76 [0.44–1.33] 8 0.77 [0.38–1.55] 0.65 [0.26–1.60]
Non-CNS solid tumours Minimal 479 1 1 555 1 1
High 47 1.30 [0.96–1.75] 1.84 [1.31–2.58] 23 1.49 [0.98–2.26] 1.79 [1.13–2.84]
  1. CNST: central nervous system tumour; HR: Hazard Ratio estimated with a Cox regression; 95%CI: 95% confidence interval
  2. 1Model adjusted for sex, birth year and year of entry
  3. 2Model adjusted for sex, birth year, year of entry, maternal age at birth, paternal and maternal occupational exposure to benzene, education level of the reference person in the household, SEP-index, degree of urbanization, residential exposure to background ionizing radiation, residential exposure to ambient NO2 (All variables assessed at entry into the cohort)