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Fig. 4 | BMC Cancer

Fig. 4

From: A machine learning approach to optimizing cell-free DNA sequencing panels: with an application to prostate cancer

Fig. 4

Variant detection and frequency distribution in prostate cancer patients using the orchid generated targeted sequencing panel. Eighteen patients with multiple tumor foci and normal tissue DNA were sequenced at 2500X-fold coverage after targeted capture using the orchid generated panel. Matched cfDNA was likewise captured and sequenced. a The number of tumor variants detected in the cfDNA of 15 patients is shown. Tumor variants were both somatic and present in multiple tumor foci. Three of the eighteen patients did not have any mutations detected in more than one focus. b The allele frequency distribution of all cfDNA detected tumor variants in A (germline threshold shown at 20%; theoretical sensitivity at 0.8%)

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