Table 2 Summary hematology results

Blood Chemistry

No Treatment

PBS

PC

Sulindac

Sulindac-PC

p value

n

6

7

7

6

5

Albumin (SD)

3.5 (0.3)

3.4 (0.3)

3.3 (0.4)

3.7 (0.2)

3.5 (0.1)

0.3

Alk Phos

109.8 (25.4)

101.9 (24.5)

92.6 (23.5)

119.0 (25.8)

88.2 (29.1)

0.3

ALT

124.7 (131.4)

350 (352.6)

237.7 (267.3)

125.7 (42.1)

95.8 (62.2)

0.3

AST

287.8 (86.4)

514.3 (500.8)

650.1 (424.0)

268.7 (99.3)

416.5 (471.8)

0.3

n

6

7

7

6

4

BUN

23.4 (4.3)

27.1 (4.7)*

18.6 (3.4)*

24.1 (4.3)

24.3 (6.3)

0.03

Globulin

1.4 (0.3)

1.4 (0.2)

1.5 (0.2)

1.5 (0.2)

1.4 (0.1)

0.7

Total Protein

4.9 (0.6)

4.9 (0.4)

4.8 (0.4)

5.2 (0.3)

5.0 (0.3)

0.3

n

2

1

2

4

4

Creatinine

0.24 (0.04)

0.20

0.24 (0.01)

0.24 (0.02)

0.22 (0.02)

0.5

n

0

1

1

0

1

Total Bilirubin

0.2

0.3

0.2

NA

Blood Chemistry

No Treatment

PBS

PC

Sulindac

Sulindac-PC

p value

n

6

7

7

6

6

Hemoglobin, g/dL (SD)

13.5 (2.5)

13.4 (0.8)

13.2 (1.8)

15.7 (1.2)

15.3 (1.3)

0.03

Hematocrit, %

49.6 (9.0)

48.1^a (3.3)

47.7^a (5.9)

58.3^b (4.7)

53.2 (3.9)

0.01

RBC count, x10e⁶/μL

9.6 (2.0)

9.3 (0.7)*

9.5 (1.3)

11.5 (0.7)*

10.8 (0.8)

0.01

WBC count, x10e³/μL

8.7 (1.6)

5.7 (2.0)

6.9 (2.7)

9.4 (3.7)

7.5 (2.4)

0.11

Platelet count, x10e³/μL

881 (375)

1049 (100)

1056 (323)

644 (310)

777 (394)

0.11