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Table 2 Multivariate COX hazards regression for OS and LCSS in IIIA/N2 NSCLC patients based on prognostic factors

From: The impact of order with radiation therapy in stage IIIA pathologic N2 NSCLC patients: a population-based study

Variables OS LCSS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR(95% Cl) P HR(95% Cl) P HR(95% Cl) P HR(95% Cl) P
Gender   <0.001   <0.001   <0.001   <0.001
 Female Reference   Reference   Reference   Reference  
 Male 0.799(0.772,0.828) <0.001 0.823(0.794,0.853) <0.001 0.823(0.792,0.855) <0.001 0.845(0.813,0.879) <0.001
Age   <0.001   <0.001   <0.001   <0.001
 < 75 Reference   Reference   Reference   Reference  
 > =75 1.645(1.582,1.710) <0.001 1.364(1.310,1.421) <0.001 1.590(1.524,1.659) <0.001 1.334(1.276,1.395) <0.001
Histology   <0.001   <0.001   <0.001   <0.001
 Adenocarcinoma Reference   Reference   Reference   Reference  
 Squamous 1.429(1.372,1.489) <0.001 1.228(1.177,1.281) <0.001 1.388(1.328,1.451) <0.001 1.193(1.139,1.250) <0.001
 Adenosquamous 1.159(1.018,1.319) 0.026 1.114(0.977,1.269) 0.106 1.138(0.988,1.312) 0.073 1.087(0.943,1.254) 0.25
 Large cell 1.248(1.125,1.384) <0.001 1.159(1.041,1.292) 0.007 1.303(1.167,1.456) <0.001 1.209(1.077,1.357) 0.001
 OTHER 1.395(1.328,1.464) <0.001 1.187(1.128,1.250) <0.001 1.411(1.339,1.488) <0.001 1.196(1.132,1.265) <0.001
Chemotherapy   <0.001   <0.001   <0.001   <0.001
 No Reference   Reference   Reference   Reference  
 Yes 0.556(0.536,0.577) <0.001 0.635(0.610,0.662) <0.001 0.586(0.563,0.610) <0.001 0.665(0.636,0.695) <0.001
Tumor Size   <0.001   <0.001   <0.001   <0.001
 ≤ 3 Reference   Reference   Reference   Reference  
 3--5 1.275(1.231,1.320) <0.001 1.221(1.178,1.266) <0.001 1.311(1.261,1.362) <0.001 1.258(1.209,1.308) <0.001
Grade   <0.001   <0.001   <0.001   <0.001
 Grade I Reference   Reference   Reference   Reference  
 Grade II 1.128(1.015,1.253) 0.025 1.134(1.020,1.260) 0.02 1.147(1.021,1.289) 0.021 1.154(1.027,1.297) 0.016
 Grade III 1.34(1.210,1.485) <0.001 1.334(1.203,1.480) <0.001 1.399(1.249,1.567) <0.001 1.386(1.235,1.554) <0.001
 Grade IV 1.593(1.351,1.880) <0.001 1.512(1.275,1.794) <0.001 1.604(1.336,1.926) <0.001 1.495(1.237,1.806) <0.001
 unknow 1.569(1.417,1.737) <0.001 1.496(1.348,1.660) <0.001 1.627(1.453,1.821) <0.001 1.544(1.377,1.732) <0.001
Radiation with surgery   <0.001   <0.001   <0.001   <0.001
 Only surgery Reference   Reference   Reference   Reference  
 Preoperative radiotherapy 0.477(0.429,0.531) <0.001 0.589(0.529,0.657) <0.001 0.507(0.452,0.568) <0.001 0.606(0.539,0.681) <0.001
 postoperative radiotherapy 0.632(0.602,0.662) <0.001 0.775(0.737,0.816) <0.001 0.645(0.612,0.679) <0.001 0.772(0.731,0.816) <0.001
 Raiotherapy both before and after sugery 0.593(0.466,0.755) <0.001 0.752(0.590,0.957) 0.021 0.56(0.426,0.736) <0.001 0.687(0.522,0.904) 0.007
 No surgery or radiation 1.052(1.010,1.095) 0.015 1.035(0.991,1.082) 0.121 1.057(1.011,1.104) 0.014 1.023(0.975,1.073) 0.356
Primary Site   <0.001   <0.001   <0.001   <0.001
 Upper lobe Reference   Reference   Reference   Reference  
 Middle lobe 1.026(0.943,1.116) 0.557 1.009(0.926,1.099) 0.833 1.053(0.962,1.153) 0.26 1.026(0.935,1.124) 0.592
 Lower lobe 1.103(1.059,1.149) <0.001 1.08(1.037,1.125) <0.001 1.102(1.054,1.151) <0.001 1.078(1.032,1.127) 0.001
 NOS 1.303(1.172,1.449) <0.001 1.314(1.172,1.474) <0.001 1.29(1.148,1.449) <0.001 1.311(1.157,1.486) <0.001
 Overlapping lesion 0.985(0.808,1.199) 0.877 1.024(0.840,1.248) 0.814 0.922(0.738,1.153) 0.478 0.945(0.756,1.182) 0.62
 Main bronchus 1.252(1.136,1.379) <0.001 1.128(1.023,1.245) 0.016 1.302(1.174,1.444) <0.001 1.171(1.054,1.301) 0.003
Laterality   0.001   <0.001   <0.001   <0.001
 Right-origin of primary Reference   Reference   Reference   Reference  
 Left-origin of primary 0.932(0.899,0.966) <0.001 0.926(0.893,0.961) <0.001 0.907(0.872,0.944) <0.001 0.904(0.868,0.941) <0.001
 Paired sit 0.836(0.633,1.104) 0.206 0.717(0.532,0.966) 0.029 0.809(0.595,1.100) 0.177 0.694(0.500,0.964) 0.029
 Only one side - side unspecified 1.556(0.861,2.810) 0.143 1.339(0.737,2.430) 0.338 1.14(0.543,2.391) 0.73 0.991(0.470,2.090) 0.982
 Not a paired site 1.266(0.408,3.927) 0.683 1.371(0.438,4.288) 0.587 1.532(0.494,4.752) 0.46 1.647(0.526,5.158) 0.392
  1. Abbreviations: NSCLC Non-small cell lung cancer, IIIA/N2 Stage IIIA pathologic N2, OS Overall survival, LCSS Lung cancer-specific survival, HRs Hazard ratios