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Table 2 Multivariate COX hazards regression for OS and LCSS in IIIA/N2 NSCLC patients based on prognostic factors

From: The impact of order with radiation therapy in stage IIIA pathologic N2 NSCLC patients: a population-based study

Variables

OS

LCSS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR(95% Cl)

P

HR(95% Cl)

P

HR(95% Cl)

P

HR(95% Cl)

P

Gender

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 Female

Reference

 

Reference

 

Reference

 

Reference

 

 Male

0.799(0.772,0.828)

<0.001

0.823(0.794,0.853)

<0.001

0.823(0.792,0.855)

<0.001

0.845(0.813,0.879)

<0.001

Age

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 < 75

Reference

 

Reference

 

Reference

 

Reference

 

 > =75

1.645(1.582,1.710)

<0.001

1.364(1.310,1.421)

<0.001

1.590(1.524,1.659)

<0.001

1.334(1.276,1.395)

<0.001

Histology

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 Adenocarcinoma

Reference

 

Reference

 

Reference

 

Reference

 

 Squamous

1.429(1.372,1.489)

<0.001

1.228(1.177,1.281)

<0.001

1.388(1.328,1.451)

<0.001

1.193(1.139,1.250)

<0.001

 Adenosquamous

1.159(1.018,1.319)

0.026

1.114(0.977,1.269)

0.106

1.138(0.988,1.312)

0.073

1.087(0.943,1.254)

0.25

 Large cell

1.248(1.125,1.384)

<0.001

1.159(1.041,1.292)

0.007

1.303(1.167,1.456)

<0.001

1.209(1.077,1.357)

0.001

 OTHER

1.395(1.328,1.464)

<0.001

1.187(1.128,1.250)

<0.001

1.411(1.339,1.488)

<0.001

1.196(1.132,1.265)

<0.001

Chemotherapy

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Yes

0.556(0.536,0.577)

<0.001

0.635(0.610,0.662)

<0.001

0.586(0.563,0.610)

<0.001

0.665(0.636,0.695)

<0.001

Tumor Size

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 ≤ 3

Reference

 

Reference

 

Reference

 

Reference

 

 3--5

1.275(1.231,1.320)

<0.001

1.221(1.178,1.266)

<0.001

1.311(1.261,1.362)

<0.001

1.258(1.209,1.308)

<0.001

Grade

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 Grade I

Reference

 

Reference

 

Reference

 

Reference

 

 Grade II

1.128(1.015,1.253)

0.025

1.134(1.020,1.260)

0.02

1.147(1.021,1.289)

0.021

1.154(1.027,1.297)

0.016

 Grade III

1.34(1.210,1.485)

<0.001

1.334(1.203,1.480)

<0.001

1.399(1.249,1.567)

<0.001

1.386(1.235,1.554)

<0.001

 Grade IV

1.593(1.351,1.880)

<0.001

1.512(1.275,1.794)

<0.001

1.604(1.336,1.926)

<0.001

1.495(1.237,1.806)

<0.001

 unknow

1.569(1.417,1.737)

<0.001

1.496(1.348,1.660)

<0.001

1.627(1.453,1.821)

<0.001

1.544(1.377,1.732)

<0.001

Radiation with surgery

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 Only surgery

Reference

 

Reference

 

Reference

 

Reference

 

 Preoperative radiotherapy

0.477(0.429,0.531)

<0.001

0.589(0.529,0.657)

<0.001

0.507(0.452,0.568)

<0.001

0.606(0.539,0.681)

<0.001

 postoperative radiotherapy

0.632(0.602,0.662)

<0.001

0.775(0.737,0.816)

<0.001

0.645(0.612,0.679)

<0.001

0.772(0.731,0.816)

<0.001

 Raiotherapy both before and after sugery

0.593(0.466,0.755)

<0.001

0.752(0.590,0.957)

0.021

0.56(0.426,0.736)

<0.001

0.687(0.522,0.904)

0.007

 No surgery or radiation

1.052(1.010,1.095)

0.015

1.035(0.991,1.082)

0.121

1.057(1.011,1.104)

0.014

1.023(0.975,1.073)

0.356

Primary Site

 

<0.001

 

<0.001

 

<0.001

 

<0.001

 Upper lobe

Reference

 

Reference

 

Reference

 

Reference

 

 Middle lobe

1.026(0.943,1.116)

0.557

1.009(0.926,1.099)

0.833

1.053(0.962,1.153)

0.26

1.026(0.935,1.124)

0.592

 Lower lobe

1.103(1.059,1.149)

<0.001

1.08(1.037,1.125)

<0.001

1.102(1.054,1.151)

<0.001

1.078(1.032,1.127)

0.001

 NOS

1.303(1.172,1.449)

<0.001

1.314(1.172,1.474)

<0.001

1.29(1.148,1.449)

<0.001

1.311(1.157,1.486)

<0.001

 Overlapping lesion

0.985(0.808,1.199)

0.877

1.024(0.840,1.248)

0.814

0.922(0.738,1.153)

0.478

0.945(0.756,1.182)

0.62

 Main bronchus

1.252(1.136,1.379)

<0.001

1.128(1.023,1.245)

0.016

1.302(1.174,1.444)

<0.001

1.171(1.054,1.301)

0.003

Laterality

 

0.001

 

<0.001

 

<0.001

 

<0.001

 Right-origin of primary

Reference

 

Reference

 

Reference

 

Reference

 

 Left-origin of primary

0.932(0.899,0.966)

<0.001

0.926(0.893,0.961)

<0.001

0.907(0.872,0.944)

<0.001

0.904(0.868,0.941)

<0.001

 Paired sit

0.836(0.633,1.104)

0.206

0.717(0.532,0.966)

0.029

0.809(0.595,1.100)

0.177

0.694(0.500,0.964)

0.029

 Only one side - side unspecified

1.556(0.861,2.810)

0.143

1.339(0.737,2.430)

0.338

1.14(0.543,2.391)

0.73

0.991(0.470,2.090)

0.982

 Not a paired site

1.266(0.408,3.927)

0.683

1.371(0.438,4.288)

0.587

1.532(0.494,4.752)

0.46

1.647(0.526,5.158)

0.392

  1. Abbreviations: NSCLC Non-small cell lung cancer, IIIA/N2 Stage IIIA pathologic N2, OS Overall survival, LCSS Lung cancer-specific survival, HRs Hazard ratios