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Table 1 Demographic and Clinical Parameters of patients with IIIA/N2 NSCLC

From: The impact of order with radiation therapy in stage IIIA pathologic N2 NSCLC patients: a population-based study

Characteristics No surgery or Radiotherapy
(n = 5512)
Surgery only
(n = 7184)
Preoperative radiotherapy
(n = 652)
Postoperative radiotherapy
(PORT, n = 4206)
Radiotherapy both before and after surgery(n = 100) P value for X2
Gender <0.001
 Male 2572(46.66%) 3680(51.22%) 329(50.46%) 2152(51.17%) 53(53.00%)
 Female 2940(53.34%) 3504(48.78%) 323(49.54%) 2054(48.83%) 47(47.00%)
Age <0.001
 < =75 3893(70.63%) 4940(68.76%) 608(93.25%) 3567(84.81%) 92(92.00%)
 > 75 1619(29.37%) 2244(31.24%) 44(6.75%) 639(15.19%) 8(8.00%)
Histologic type <0.001
 Adenocarcinoma 2081(37.75%) 3831(53.33%) 342(52.45%) 2486(59.11%) 65(65.00%)
 Squamous 2118(38.43%) 1922(26.75%) 173(26.53%) 1003(23.85%) 19(19.00%)
 Adenosquamous 67(1.22%) 158(2.20%) 17(2.61%) 88(2.09%) 1(1.00%)
 Large cell 144(2.61%) 201(2.80%) 23(3.53%) 129(3.07%) 1(1.00%)
 OTHER 1102(19.99%) 1072(14.92%) 97(14.88%) 500(11.89%) 14(14.00%)
Tumor Size (cm) <0.001
 ≤ 3 2318(42.05%) 3765(52.41%) 295(45.25%) 2483(59.03%) 47(47.00%)  
 3–5 3194(57.95%) 3419(47.59%) 357(54.85%) 1723(40.97%) 53(53.00%)
Race <0.001
 White 4444(80.62%) 5810(80.87%) 544(83.44%) 3436(81.69%) 78(78.00%)
 Black 763(13.84%) 802(11.16%) 68(10.43%) 482(11.46%) 9(9.00%)
 Others 297(5.39%) 553(7.70%) 40(6.13%) 281(6.68%) 13(13.00%)
 Unknown 8(0.15%) 19(0.27%) 0(0.00%) 7(0.17%) 0(0.00%)
Primary Site <0.001
 Upper lobe 3454(62.66%) 4302(59.88%) 447(68.56%) 2628(62.48%) 65(65.00%)
 Middle lobe 241(4.37%) 326(4.54%) 34(5.21%) 226(5.37%) 5(5.00%)
 Lower lobe 1337(24.26%) 2141(29.80%) 138(21.17%) 1098(26.11%) 27(27.00%)
 NOS 155(2.81%) 195(2.71%) 9(1.38%) 123(2.92%) 0(0.00%)
 Overlapping lesion 33(0.60%) 64(0.89%) 6(0.92%) 28(0.67%) 2(2.00%)
 Main bronchus 292(5.30%) 156(2.17%) 18(2.76%) 103(2.45%) 1(1.00%)
Grade <0.001
 Grade I 154(2.79%) 327(4.55%) 23(3.53%) 138(3.28%) 3(3.00%)
 Grade II 900(16.33%) 1935(26.93%) 138(21.17%) 1021(24.27%) 26(26.00%)
 Grade III 1722(31.24%) 2427(33.78%) 278(42.64%) 1361(32.36%) 39(39.00%)
 Grade IV 83(1.51%) 122(1.70%) 5(0.77%) 62(1.47%) 3(3.00%)
 unknown 2653(48.13%) 2373(33.03%) 208(31.90%) 1624(38.61%) 29(29.00%)
Laterality 0.001
 Right-origin of primary 3421(62.06%) 4316(60.08%) 405(62.12%) 2631(62.55%) 67(67.00%)
 Left-origin of primary 2063(37.43%) 2840(39.53%) 246(37.73%) 1531(36.40%) 33(33.00%)
 Paired sit 23(0.42%) 20(0.28%) 1(0.15%) 38(0.90%) 0(0.00%)
 Only one side - side unspecified 4(0.07%) 6(0.08%) 0(0.00%) 4(0.10%) 0(0.00%)
 Not a paired site 1(0.02%) 2(0.03%) 0(0.00%) 2(0.05%) 0(0.00%)  
Insurance status <0.001
 Medicaid 594(10.78%) 768(10.70%) 45(6.90%) 399(9.49%) 7(7.00%)
 Uninsured 101(1.83%) 118(1.65%) 10(1.53%) 59(1.40%) 2(2.00%)
 Unknown 1316(23.88%) 1858(25.86%) 180(27.61%) 847(20.14%) 29(29.00%)
 Insured 3501(63.52) 4440(61.80%) 417(63.96%) 2901(68.97%) 62(62.00%)
Marital status <0.001
 Married 2812(51.02%) 3644(50.72%) 393(60.28%) 2440(58.01%) 58(58.00%)
 Single 671(12.17%) 887(12.35%) 76(11.66%) 467(11.10%) 12(12.00%)
 Divorced 681(12.35%) 903(12.57%) 93(14.26%) 540(12.84%) 12(12.00%)
 widowed 1079(19.6%) 1401(19.50%) 63(9.66%) 574(13.65%) 11(11.00%)
 Unknown 181(3.28%) 262(3.65%) 20(3.07%) 131(3.11%) 1(1.00%)
 Unmarried or domestic partner 6(0.11%) 12(0.17%) 1(0.15%) 12(0.29%) 0(0.00%)
 Separated 82(1.49%) 75(1.04%) 6(0.92%) 42(1.00%) 6(6.00%)
Year of diagnosis <0.001
 2004–2007 1756(31.86%) 2399(33.39%) 241(36.96%) 1105(26.27%) 37(37.00%)
 2008–2011 1982(35.96%) 2437(33.92%) 216(33.13%) 1326(31.53%) 35(35.00%)
 2012–2017 1774(32.18%) 2348(32.68%) 195(29.91%) 1775(42.20%) 28(28.00%)
Region <0.001
 EAST 2733(49.58%) 3243(45.14%) 283(43.40%) 2148(51.07%) 38(38.00%)
 NORTHWEST 1965(35.65%) 3082(42.90%) 265(40.64%) 1417(33.69%) 50(50.00%)
 SOUTHWEST 661(11.99%) 647(9.01%) 86(13.19%) 561(13.34%) 10(10.00%)
 Pacific Coast 153(2.78%) 212(2.95%) 18(2.76%) 80(1.90%) 2(2.00%)
High school education <0.001
 ≥ 21 977(17.72%) 1524(21.21%) 102(15.64%) 590(14.03%) 19(19.00%)
 13–20 1823(33.07%) 2293(31.92%) 159(24.39%) 1199(28.51%) 32(32.00%)
 7–12.99 2363(42.87%) 2968(41.31%) 344(52.76%) 2101(49.95%) 41(41.00%)
 < 7 349(6.33%) 399(5.55%) 47(7.21%) 316(7.51%) 8(8.00%)
Median household income, in tens <0.001
 < 38,000 422(7.66%) 570(7.927%) 28(4.29%) 290(6.89%) 5(5.00%)
 38,000–47,999 1080(19.59%) 1097(15.27%) 88(13.50%) 731(17.38%) 14(14.00%)
 48,000–62,999 2064(37.45%) 2842(39.56%) 276(42.33%) 1588(37.76%) 40(40.00%)
  > 63,000 1946(35.30%) 2675(37.24%) 260(39.88%) 1597(37.97%) 41(41.00%)
Chemotherapy <0.001
 Yes 4221(76.58%) 3184(44.32%) 631(96.78%) 3791(90.13%) 96(96.00%)
 no 1291(23.42%) 4000(55.68%) 21(3.22%) 415(9.87%) 4(4.00%)
  1. Abbreviations: NSCLC Non-small cell lung cancer, IIIA/N2 Stage IIIA pathologic N2