Fig. 1

a Overview of major characteristics of the cohort, distribution of age, gender and tumor localization (b) A scatter plot indicate the correlation between T1 contrast enriched volume and T2-hyperintensity volume. c A waterfall plot illustrates the minimal and maximal volume (T2-hyperintensity) and the volume at first diagnosis, colors indicate the determined WHO grade. d Line plots show individual growth curves based on T2-hyperintensity changes over the course of the disease. Each patient is colored differently. Time marked the individual course of the disease, Timpoint:0; Day of initial diagnosis. e Heatmap of loess fitted growth curved (Time ~ T2-hyperintensity changes), darker colors show less growth, brighter colors indicate timepoints of increased growing. At the left side, clinical characteristics are aligned to each patient (as rows). On the right side, an example of one patient was shown in order to improve understanding of the heatmap, including the heatmap, growth curve and corresponding T2-MRI images. At the right bottom, the color code for clinical parameters is given