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Table 4 Subgroup analyses of the association between dietary insulinemic potential and colorectal cancer-specific and all-cause mortality

From: Post-diagnosis dietary insulinemic potential and survival outcomes among colorectal cancer patients

Subgroup

Deaths/Patients alive

EDIH quintiles

P-trend

P-interaction

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Colorectal cancer-specific mortality

 Sex

      

0.48

  Men

83/517

1 (ref)

1.15 (0.60, 2.18)

1.09 (0.56, 2.12)

1.02 (0.50, 2.08)

0.98

 

 Women

189/929

1 (ref)

1.19 (0.76, 1.89)

1.41 (0.90, 2.21)

1.71 (1.01, 2.88)

0.03

 

 Weight change (post minus pre-diagnosis weight)

     

0.18

  Stable weight (−2.5 to 2.5 kg)

98/616

1 (ref)

1.13 (0.63, 2.05)

1.37 (0.76, 2.48)

1.04 (0.51, 2.13)

0.73

 

  Weight gain > 2.5 kg

66/359

1 (ref)

1.01 (0.50, 2.02)

0.99 (0.46, 2.14)

1.18 (0.50, 2.80)

0.73

 

  Weight loss > 2.5 kg

108/471

1 (ref)

1.38 (0.70, 2.32)

1.91 (0.99, 3.68)

2.76 (1.32, 5.60)

0.003

 

 Pre-diagnosis EDIH score

      

0.06

   < Median

130/737

1 (ref)

1.19 (0.77, 1.83)

0.86 (0.51, 1.45)

0.92 (0.45, 1.87)

0.66

 

   ≥ Median

142/708

1 (ref)

1.19 (0.52, 2.71)

2.00 (0.95, 4.24)

2.13 (0.99, 4.58)

0.01

 

 Age group at diagnosis

      

0.54

   < 65 years

107/487

1 (ref)

0.89 (0.49, 1.62)

1.03 (0.58, 1.83)

1.39 (0.73, 2.64)

0.29

 

   ≥ 65 years

165/959

1 (ref)

1.29 (0.80, 2.07)

1.58 (0.97, 2.58)

1.32 (0.76, 2.29)

0.28

 

 Time since diagnosis

      

0.41

   < 5 years

207/221

1 (ref)

0.91 (0.58, 1.43)

0.98 (0.63, 1.52)

1.40 (0.86, 2.30)

0.16

 

   ≥ 5 years

65/1225

1 (ref)

0.97 (0.47, 2.01)

1.08 (0.53, 2.23)

0.56 (0.22, 1.38)

0.26

 

All-cause mortality

 Sex

      

0.001

  Men

398/202

1 (ref)

1.13 (0.85, 1.52)

0.84 (0.61, 1.16)

0.90 (0.65, 1.25)

0.36

 

  Women

610/508

1 (ref)

1.23 (0.96, 1.57)

1.62 (1.27, 2.08)

1.72 (1.29, 2.31)

< 0.0001

 

 Weight change (post minus prediagnosis weight)

     

0.57

  Stable weight (−2.5 to 2.5 kg)

379/335

1 (ref)

1.35 (1.00, 1.81)

1.46 (1.07, 2.00)

1.30 (0.91, 1.86)

0.13

 

  Weight gain > 2.5 kg

241/184

1 (ref)

0.85 (0.57, 1.28)

1.09 (0.72, 1.66)

1.28 (0.80, 2.06)

0.18

 

  Weight loss > 2.5 kg

388/191

1 (ref)

1.22 (0.89, 1.67)

1.30 (0.94, 1.80)

1.57 (1.10, 2.25)

0.01

 

 Prediagnosis EDIH score

      

0.16

   < Median

487/380

1 (ref)

1.27 (1.01, 1.59)

1.12 (0.85, 1.48)

1.42 (1.02, 1.96)

0.05

 

   ≥ Median

521/330

1 (ref)

1.15 (0.79, 1.66)

1.48 (1.06, 2.08)

1.36 (0.96, 1.93)

0.07

 

 Age group at diagnosis

      

0.75

   < 65 years

265/329

1 (ref)

1.10 (0.74, 1.63)

1.41 (0.96, 2.05)

1.67 (1.10, 2.52)

0.009

 

   ≥ 65 years

743/381

1 (ref)

1.16 (0.94, 1.44)

1.26 (1,00, 1.58)

1.22 (0.94, 1.57)

0.12

 

 Time since diagnosis

      

0.79

   < 5 years

394/34

1 (ref)

1.09 (0.79, 1.48)

1.18 (0.86, 1.62)

1.34 (0.94, 1.93)

0.08

 

   ≥ 5 years

614/676

1 (ref)

1.10 (0.87, 1.39)

1.22 (0.95, 1.56)

1.26 (0.95, 1.66)

0.09

 
  1. Models were adjusted for age at diagnosis, postdiagnosis body mass index, total energy intake, sex, race, year of diagnosis, cancer stage, grade of tumor differentiation, and location of primary tumor within the colon, postdiagnosis physical activity, postdiagnosis pack years of smoking, postdiagnosis regular aspirin use, weight change pre to postdiagnosis and postdiagnosis total alcohol intake, and pre-diagnosis EDIH score
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BMC Cancer

ISSN: 1471-2407

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