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Table 4 Subgroup analyses of the association between dietary insulinemic potential and colorectal cancer-specific and all-cause mortality

From: Post-diagnosis dietary insulinemic potential and survival outcomes among colorectal cancer patients

Subgroup Deaths/Patients alive EDIH quintiles P-trend P-interaction
Quartile 1 Quartile 2 Quartile 3 Quartile 4
Colorectal cancer-specific mortality
 Sex        0.48
  Men 83/517 1 (ref) 1.15 (0.60, 2.18) 1.09 (0.56, 2.12) 1.02 (0.50, 2.08) 0.98  
 Women 189/929 1 (ref) 1.19 (0.76, 1.89) 1.41 (0.90, 2.21) 1.71 (1.01, 2.88) 0.03  
 Weight change (post minus pre-diagnosis weight)       0.18
  Stable weight (−2.5 to 2.5 kg) 98/616 1 (ref) 1.13 (0.63, 2.05) 1.37 (0.76, 2.48) 1.04 (0.51, 2.13) 0.73  
  Weight gain > 2.5 kg 66/359 1 (ref) 1.01 (0.50, 2.02) 0.99 (0.46, 2.14) 1.18 (0.50, 2.80) 0.73  
  Weight loss > 2.5 kg 108/471 1 (ref) 1.38 (0.70, 2.32) 1.91 (0.99, 3.68) 2.76 (1.32, 5.60) 0.003  
 Pre-diagnosis EDIH score        0.06
   < Median 130/737 1 (ref) 1.19 (0.77, 1.83) 0.86 (0.51, 1.45) 0.92 (0.45, 1.87) 0.66  
   ≥ Median 142/708 1 (ref) 1.19 (0.52, 2.71) 2.00 (0.95, 4.24) 2.13 (0.99, 4.58) 0.01  
 Age group at diagnosis        0.54
   < 65 years 107/487 1 (ref) 0.89 (0.49, 1.62) 1.03 (0.58, 1.83) 1.39 (0.73, 2.64) 0.29  
   ≥ 65 years 165/959 1 (ref) 1.29 (0.80, 2.07) 1.58 (0.97, 2.58) 1.32 (0.76, 2.29) 0.28  
 Time since diagnosis        0.41
   < 5 years 207/221 1 (ref) 0.91 (0.58, 1.43) 0.98 (0.63, 1.52) 1.40 (0.86, 2.30) 0.16  
   ≥ 5 years 65/1225 1 (ref) 0.97 (0.47, 2.01) 1.08 (0.53, 2.23) 0.56 (0.22, 1.38) 0.26  
All-cause mortality
 Sex        0.001
  Men 398/202 1 (ref) 1.13 (0.85, 1.52) 0.84 (0.61, 1.16) 0.90 (0.65, 1.25) 0.36  
  Women 610/508 1 (ref) 1.23 (0.96, 1.57) 1.62 (1.27, 2.08) 1.72 (1.29, 2.31) < 0.0001  
 Weight change (post minus prediagnosis weight)       0.57
  Stable weight (−2.5 to 2.5 kg) 379/335 1 (ref) 1.35 (1.00, 1.81) 1.46 (1.07, 2.00) 1.30 (0.91, 1.86) 0.13  
  Weight gain > 2.5 kg 241/184 1 (ref) 0.85 (0.57, 1.28) 1.09 (0.72, 1.66) 1.28 (0.80, 2.06) 0.18  
  Weight loss > 2.5 kg 388/191 1 (ref) 1.22 (0.89, 1.67) 1.30 (0.94, 1.80) 1.57 (1.10, 2.25) 0.01  
 Prediagnosis EDIH score        0.16
   < Median 487/380 1 (ref) 1.27 (1.01, 1.59) 1.12 (0.85, 1.48) 1.42 (1.02, 1.96) 0.05  
   ≥ Median 521/330 1 (ref) 1.15 (0.79, 1.66) 1.48 (1.06, 2.08) 1.36 (0.96, 1.93) 0.07  
 Age group at diagnosis        0.75
   < 65 years 265/329 1 (ref) 1.10 (0.74, 1.63) 1.41 (0.96, 2.05) 1.67 (1.10, 2.52) 0.009  
   ≥ 65 years 743/381 1 (ref) 1.16 (0.94, 1.44) 1.26 (1,00, 1.58) 1.22 (0.94, 1.57) 0.12  
 Time since diagnosis        0.79
   < 5 years 394/34 1 (ref) 1.09 (0.79, 1.48) 1.18 (0.86, 1.62) 1.34 (0.94, 1.93) 0.08  
   ≥ 5 years 614/676 1 (ref) 1.10 (0.87, 1.39) 1.22 (0.95, 1.56) 1.26 (0.95, 1.66) 0.09  
  1. Models were adjusted for age at diagnosis, postdiagnosis body mass index, total energy intake, sex, race, year of diagnosis, cancer stage, grade of tumor differentiation, and location of primary tumor within the colon, postdiagnosis physical activity, postdiagnosis pack years of smoking, postdiagnosis regular aspirin use, weight change pre to postdiagnosis and postdiagnosis total alcohol intake, and pre-diagnosis EDIH score