Fig. 3

Hazard ratios for the association of change in dietary insulinemic potential between pre-diagnosis diet and post-diagnosis diet and risk of dying form colorectal cancer (CRC-survival) and from all causes combined (overall survival). EDIH scores were dichotomized at the median: Low-Low, the reference category, represents participants who persistently consumed low insulinemic diets (below the median EDIH) from pre to post-diagnosis period; Low-High are those who changed from low insulinemic diets towards more hyperinsulinemic diets; High-Low represents those who changed from consuming hyperinsulinemic diets prior to diagnosis towards consuming low insulinemic diets after diagnosis, whereas High-High represents those who persistently consumed hyperinsulinemic diets prior to diagnosis and after diagnosis. The number of deaths / patients alive in the four categories were as follows: CRC-survival: Low-Low 97/541, Low-High 33/196, High-Low 30/205, High-High 112/504; Overall survival: Low-Low 347/291, Low-High 140/89, High-Low 139/96, High-High 382/234. Models were adjusted for age at diagnosis, post-diagnosis body mass index, total energy intake, sex, race, year of diagnosis, cancer stage, grade of tumor differentiation, location of primary tumor within the colon, post-diagnosis physical activity, post-diagnosis pack years of smoking, post-diagnosis regular aspirin use, weight change pre to post-diagnosis, post-diagnosis total alcohol intake, and pre-diagnosis EDIH score