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Fig. 4 | BMC Cancer

Fig. 4

From: An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

Fig. 4

AMPK inactivation drives oncogenic transcriptional alterations in diverse biological processes and signaling modules. a Venn diagram illustrates the number of differentially expressed genes (DEGs) between 1st and 4th quartile patients, as stratified using the 24-AMPK-gene set, in four cancer types. A total of 122 DEGs were common in all four cancers. b Dot plots depict the number of significantly enriched pathways and biological processes upon the mapping of DEGs to KEGG, Gene Ontology and Reactome databases. Each dot represents an enriched event. c Ontologies that exhibit similar patterns of enrichment across four cancers are shown. DEGs are also mapped to ENCODE and ChEA transcription factor (TF) databases to determine enriched TF binding associated with DEGs

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