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Table 2 Predictive potential of SOCS1/SOCS3 and oncogenic signalling pathway in the Cox proportional hazard model

From: Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Selected gene Combinations Oncogenic signaling Pathway Multivariate Cox model p-value Univariate log-rank p-value Survival probability Number of subjects HR [95% confidence intervals]
Low SOCS1
+ High CDK1
Cell cycle 0.0152 0.0153 Poor 17 2.56 [1.28–5.11]
Low SOCS1
+ High CXCL8
RTK signalling, angiogenesis < 0.0001 < 0.0001 Poor 4 7.97 [2.85–22.25]
Low SOCS1
+ High IGF1Ra
RTK signalling, angiogenesis 0.0051 0.007 Poor 6 5.98 [2.09–17.13]
Low SOCS1
+ High CSF1
Proliferation 0.0042 0.0042 Poor 11 2.62 [1.19–5.78]
Low SOCS1
+ High DAB2
MAPK pathway < 0.0001 < 0.0001 Poor 8 7.73 [3.45–17.35]
Low SOCS1
+ Low PIK3R1
PI3K-AKT pathway 0.0102 0.0102 Poor 9 3.52 [1.55–8.01]
Low SOCS1
+ High TSC1
PI3K-AKT pathway 0.0248 0.0274 Poor 24 2.84 [1.50–5.38]
Low SOCS1
+ High RAF1a
MAPK pathway 0.0046 0.0291 Better 28 0.281 [0.11–0.71]
Low SOCS1
+ High AKT1S1
PI3K-AKT pathway 0.0034 0.0187 Better 15 0.08 [0.02–0.36]
Low SOCS1
+ Low PIK3R2b
PI3K-AKT pathway 0.0192 0.0344 Better 28 0.224 [.08–0.65]
Low SOCS3a
+ High RBL1
Cell cycle 0.0053 0.0123 Poor 23 2.20 [1.20–4.03]
Low SOCS3a
+ High CXCL8
RTK signalling, angiogenesis 0.0017 0.0017 Poor 3 7.03 [1.70–28.99]
Low SOCS3a
+ High FGFR1a
Proliferation 0.0125 0.0173 Poor 4 4.15 [1.31–13.17]
Low SOCS3a
+ Low DLEC1a
Proliferation 0.0163 0.0324 Poor 22 2.01 [1.12–3.58]
Low SOCS3a
+ High DAB2
MAPK pathway 0.0023 0.0023 Poor 10 3.42 [1.49–7.84]
Low SOCS3a
+ High PIK3R1b
PI3K-AKT pathway 0.0232 0.0232 Better 27 0.21 [0.07–0.6]
  1. All possible combinations of SOCS1 or SOCS3 with all query genes were analysed in the Cox proportional hazards model as described in materials and methods. High or low expression of individual genes have poor prognosis in univariate analysis unless indicated otherwise: aNo prognostic value; bGood prognosis. Genes in bold face show synergy with both low SOCS1 and low SOCS3
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