Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Khan, Md Gulam Musawwir; Ghosh, Amit; Variya, Bhavesh; Santharam, Madanraj Appiya; Ihsan, Awais Ullah; Ramanathan, Sheela; Ilangumaran, Subburaj

doi:10.1186/s12885-020-07285-3

Table 2 Predictive potential of SOCS1/SOCS3 and oncogenic signalling pathway in the Cox proportional hazard model

From: Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Selected gene Combinations	Oncogenic signaling Pathway	Multivariate Cox model p-value	Univariate log-rank p-value	Survival probability	Number of subjects	HR [95% confidence intervals]
Low SOCS1 + High CDK1	Cell cycle	0.0152	0.0153	Poor	17	2.56 [1.28–5.11]
Low SOCS1 + High *CXCL8*	RTK signalling, angiogenesis	< 0.0001	< 0.0001	Poor	4	7.97 [2.85–22.25]
Low SOCS1 + High IGF1R^a	RTK signalling, angiogenesis	0.0051	0.007	Poor	6	5.98 [2.09–17.13]
Low SOCS1 + High CSF1	Proliferation	0.0042	0.0042	Poor	11	2.62 [1.19–5.78]
Low SOCS1 + High *DAB2*	MAPK pathway	< 0.0001	< 0.0001	Poor	8	7.73 [3.45–17.35]
Low SOCS1 + Low PIK3R1	PI3K-AKT pathway	0.0102	0.0102	Poor	9	3.52 [1.55–8.01]
Low SOCS1 + High TSC1	PI3K-AKT pathway	0.0248	0.0274	Poor	24	2.84 [1.50–5.38]
Low SOCS1 + High RAF1^a	MAPK pathway	0.0046	0.0291	Better	28	0.281 [0.11–0.71]
Low SOCS1 + High AKT1S1	PI3K-AKT pathway	0.0034	0.0187	Better	15	0.08 [0.02–0.36]
Low SOCS1 + Low PIK3R2^b	PI3K-AKT pathway	0.0192	0.0344	Better	28	0.224 [.08–0.65]
Low SOCS3^a + High RBL1	Cell cycle	0.0053	0.0123	Poor	23	2.20 [1.20–4.03]
Low SOCS3^a + High *CXCL8*	RTK signalling, angiogenesis	0.0017	0.0017	Poor	3	7.03 [1.70–28.99]
Low SOCS3^a + High FGFR1^a	Proliferation	0.0125	0.0173	Poor	4	4.15 [1.31–13.17]
Low SOCS3^a + Low DLEC1^a	Proliferation	0.0163	0.0324	Poor	22	2.01 [1.12–3.58]
Low SOCS3^a + High *DAB2*	MAPK pathway	0.0023	0.0023	Poor	10	3.42 [1.49–7.84]
Low SOCS3^a + High PIK3R1^b	PI3K-AKT pathway	0.0232	0.0232	Better	27	0.21 [0.07–0.6]

All possible combinations of SOCS1 or SOCS3 with all query genes were analysed in the Cox proportional hazards model as described in materials and methods. High or low expression of individual genes have poor prognosis in univariate analysis unless indicated otherwise: ^aNo prognostic value; ^bGood prognosis. Genes in bold face show synergy with both low SOCS1 and low SOCS3

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ISSN: 1471-2407

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