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Fig. 2 | BMC Cancer

Fig. 2

From: Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

Fig. 2

Cell cycle regulation genes predominantly show a positive correlation with SOCS1 and SOCS3. a Heatmap showing negative (mutual exclusivity) or positive (co-expression) correlation between cell cycle genes and SOCS1 or SOCS3 in the TCGA-LIHC dataset. The extremities of Spearman’s rank correlation coefficient (ρ) are aligned for SOCS1, with the color scale shown at right. The ρ-value of − 1 and 1 (green to red) implies a stronger linear relationship of mutual exclusivity and co-occurrence, respectively. Asterisks within the heatmap indicate the statistical significance of the Spearman correlation. Blue circles on the left indicate Genes showing statistically significant negative correlation with SOCS1 and yellow circles on the right mark genes showing mutual exclusivity with SOCS3. b Genes that show significant negative correlation with SOCS1 and/or SOCS3 were evaluated for their expression levels in HCC tumors compared to normal liver tissues. c Prognostic potential of the above genes was evaluated by comparing the upper quartile of high expression against the remaining three-quarts of low/medium expression by Kaplan-Meier plot. For genes showing statistically significant prognostic potential, with high gene expression correlating poor overall survival, the p-values are indicated in red-color font

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