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Table 2 Histopathological changes of patients with CRCLM after NC

From: Quantified MRI and 25OH-VitD3 can be used as effective biomarkers for patients with neoadjuvant chemotherapy-induced liver injury in CRCLM?

2A Histopathological features

Value

Percentage (%)

Hepatocellular ballooning

31

75.6

Focal or bridging necrosis

28

68.9

Eosinophilic infiltration

29

71.1

Bile ducts damage

22

53.3

Hepatic sinus widening

15

37.8

Kupper hyperplasia

10

24.4

Collagen accumulation

2

4.44

Clastic necrosis in the portal area

2

4.44

2B His-Scores

Grade 0

Grade 1

Grade2

Grade 3

CASH*

8 (19.5%)

22 (53.7%)

11 (26.8%)

–

SOS*

10 (24.4%)

23 (56.1%)

8 (9.76%)

–

CASH & SOS

7 (17.1%)

23 (56.1%)

11 (26.8%)

–

  1. *CASH, nonalcoholic steatohepatitis, SOS sinusoidal obstruction syndrome