Table 2 Comparison of clinicopathological characteristics before and after PSM in neoadjuvant group
Patient Characteristics | Unmatched comparison | Matched comparison | ||||
|---|---|---|---|---|---|---|
Patients with NEC components (n = 63) | Gastric adenocarcinoma (n = 477) | P value | Patients with NEC components (n = 60) | Gastric adenocarcinoma (n = 120) | P value | |
Age (year), mean ± SD | 61.2 ± 9.6 | 58.3 ± 10.3 | 0.037 | 61.3 ± 9.7 | 60.2 ± 9.5 | 0.484 |
Gender (male/female) | 52/11 | 367/110 | 0.316 | 50/10 | 104/16 | 0.549 |
BMI, mean ± SD | 24.1 ± 3.9 | 23.5 ± 3.4 | 0.285 | 23.9 ± 3.9 | 23.8 ± 3.4 | 0.855 |
Adjuvant therapy | 0.124 | 0.173 | ||||
Yes | 58 (92.1) | 459 (96.2) | 56 (93.9) | 117 (97.5) | ||
No | 5 (7.9) | 18 (3.8) | 4 (6.7) | 3 (2.5) | ||
Tumor location | < 0.001 | 0.361 | ||||
Upper third | 46 (73.0) | 222 (46.5) | 43 (71.7) | 79 (65.8) | ||
Middle third | 9 (14.3) | 50 (10.5) | 9 (15.0) | 13 (10.8) | ||
Lower third | 7 (11.1) | 189 (39.6) | 7 (11.7) | 21 (17.5) | ||
Entire | 1 (1.6) | 16 (3.4) | 1 (1.7) | 7 (5.8) | ||
Tumor size | 0.325 | 0.594 | ||||
< 5 cm | 36 (57.1) | 303 (63.5) | 33 (55.0) | 71 (59.2) | ||
≥ 5 cm | 27 (42.9) | 174 (36.5) | 27 (45.0) | 49 (40.8) | ||
Type of gastrectomy | < 0.001 | 0.974 | ||||
Total gastrectomy | 50 (79.4) | 239 (50.1) | 47 (78.3) | 94 (78.3) | ||
Distal gastrectomy | 7 (11.1) | 181 (37.9) | 7 (11.7) | 15 (12.5) | ||
Proximal gastrectomy | 6 (9.5) | 57 (11.9) | 6 (10.0) | 11 (9.2) | ||
Surgical procedure | 0.394 | 1.000 | ||||
Open | 60 (95.2) | 440 (92.2) | 57 (95.0) | 114 (95.0) | ||
Laparoscopic | 3 (4.8) | 37 (7.8) | 3 (5.0) | 6 (5.0) | ||
T stage | < 0.001 | 0.065 | ||||
T0 | 1 (1.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
T1 | 3 (4.8) | 28 (5.9) | 3 (5.0) | 3 (2.5) | ||
T2 | 3 (4.8) | 60 (12.6) | 3 (5.0) | 15 (12.5) | ||
T3 | 35 (55.6) | 154 (32.3) | 34 (56.7) | 47 (39.2) | ||
T4 | 21 (33.3) | 235 (49.6) | 20 (33.3) | 55 (45.8) | ||
N stage | 0.017 | 0.186 | ||||
N0 | 17 (27.0) | 158 (33.1) | 16 (26.7) | 44 (36.7) | ||
N1 | 22 (34.9) | 99 (20.8) | 21 (35.0) | 33 (27.5) | ||
N2 | 14 (22.2) | 80 (16.8) | 14 (23.3) | 17 (14.2) | ||
N3 | 10 (15.9) | 140 (29.4) | 9 (15.0) | 26 (21.7) | ||
M stage | 0.041 | 0.721 | ||||
M0 | 60 (95.2) | 471 (98.7) | 59 (98.3) | 117 (97.5) | ||
M1 | 3 (4.8) | 6 (1.3) | 1 (1.7) | 3 (2.5) | ||
ypTNM stage | 0.001 | 0.950 | ||||
0 | 1 (1.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
I | 4 (6.3) | 52 (10.9) | 4 (6.7) | 6 (5.0) | ||
II | 31 (49.2) | 163 (34.2) | 31 (51.7) | 64 (53.3) | ||
III | 24 (38.1) | 256 (53.7) | 24 (40.0) | 47 (39.2) | ||
IV | 3 (4.8) | 6 (1.3) | 1 (1.7) | 3 (2.5) | ||