Fig. 6

Correlations between S1PR1 expression and immune infiltration levels in breast and lung cancer. a S1PR1 expression was significantly negatively related to tumor purity and significantly positively correlated with infiltrating levels of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in BRCA (n = 1093). b S1PR1 expression was significantly negatively related to tumor purity and was significant positively correlated with infiltrating levels of CD8+ T cells, CD4+ T cells, and dendritic cells in BRCA-Basal (n = 139). c S1PR1 expression was significantly negatively related to tumor purity and was significantly positively correlated with infiltrating levels of CD8+ T cells, CD4+ T cells, neutrophils, and dendritic cells in BRCA-Her2 (n = 67). d S1PR1 expression was significantly negatively related to tumor purity and was significantly positively correlated with infiltrating levels of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in BRCA-Luminal (n = 611). e S1PR1 expression was significantly negatively related to tumor purity and was significantly positively correlated with infiltrating levels of CD8+ T cells, macrophages, neutrophils, and dendritic cells in LUAD (n = 457). f S1PR1 expression was significantly negatively related to tumor purity and was significant positively correlated with infiltrating levels of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells in LUSC (n = 457). Spearman’s correlation coefficients were used for analyses. * P < 0.01; ** P < 0.001; *** P < 0.0001