Fig. 1

SNHG3 was upregulated in BC. a. Volcano map of lncRNAs between BC and benign breast lesions specimens by transcriptome analysis. The blue dots indicated high lncRNA expression; the red dots indicated low lncRNA expression and the black dots showed the lncRNAs with an expression of |log2FC| < 2. Log2FC was logarithm of fold-change with base 2 and the fold-change was cancer over normal. The Y axis represented an adjusted FDR, and the X axis represented the log2FC value. Aberrantly expressed lncRNAs were identified by DESeq R. Altogether, 137 highly expressed and 139 low expressed lncRNAs were identified; b. Different expressions of the top 8 lncRNAs between BC and benign breast lesions specimens by RT-qPCR; c. SNHG3 expression in normal tissue and primary tumor assessed by UALCAN; d. SNHG3 level among BC cell lines and human mammary epithelial cells detected using RT-qPCR. Three independent experiments were performed. Data are expressed as mean ± standard deviation; one-way ANOVA and Tukey’s multiple comparisons test was used, *p < 0.05, **p < 0.01